Application of PHA Granule Surface Proteins

It appears that the proteins locating on the in vivo PHA granule surface could be potential affinity tags for protein purification. Among the nonspecific PHA granule-binding protein phasin as a hydrophobic affinity tag appears to be the most attractive because of its richness compared with others. 

This system was successful to produce and purify the enhanced green fluorescent protein (EGFP), maltase binding protein (MBP), and P-galactosidase. Using this technique allows the production and purification of high value added proteins in a continuous way with low cost [65]. 

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