Graft thrombosis

Schaffer LW, Davidson JT, Vlasuk GP, Dunwiddie CT, Siegel PKS. Selective factor Xa inhibition by recombinant antistasin prevents vascular graft thrombosis in baboons. Arteriosclerosis and Thromb 1992 12 879-885. 

A scientific registry of transplant recipients has been used to determine the effect of cadaveric organ donor treatment with desmopressin on the incidence of pancreas graft thrombosis in clinical pancreas transplantation (70). Of 2804 cases with sufficient information between 5 April 1994 and 27 September 2002, 1287 (46%) had received desmopressin. The mean follow up was 1.5 years (1 month to 8.4 years). There was pancreatic graft thrombosis in 4.3%, of whom 5.1% had received desmopressin and 3.5% had not this was just statistically significant. There was no information about dose, time-course, or duration of desmopressin use. It is not known whether this finding is clinically significant. 

Marques RG, Rogers J, Chavin KD, Baliga PK, Lin A, Emovon O, Afzal F, Baillie GM, Taber DJ, Ashcraft EE, Rajagopalan PR. Does treatment of cadaveric organ donors with desmopressin increase the likelihood of pancreas graft thrombosis Results of a preliminary study. Transplant Proc 2004 36 1048-9. 

Me Goff MA, Allen BT,DerT,Sicard GA, Santoro SA. Mechanisms ofvascular graft thrombosis role of altered canine platelet sensitivity to thromboxane. Thromb Res 1989 55 695-707... 

The issue of whether the use of aprotinin is associated with an increased risk of vein graft thrombosis in cardiac bypass surgery has not been resolved (14,15). The use of... 

Kalangos A, Tayyareci G, Pretre R, Di Dio P, Sezerman O. Influence of aprotinin on early graft thrombosis in patients undergoing myocardial revascularization. Eur J Cardiothorac Surg 1994 8(12) 651-6. 

If epoetin is given preoperatively without autologous predonation, there is an increased risk of hypertension, an increased risk of graft thrombosis and myocardial infarction in cardiac surgery, and an increased risk of venous thromboembolism in orthopedic patients (71). 

Type V/endotension persistent elevation of the pressure (>60 mmHg), leading to a risk of rupture without blood flow into the lesion. This can lead to graft thrombosis, endoleaks or aneurysm rupture (Fillinger 1999). 

Kaufman JS, O Connor TZ, Zhang JH, et al Veterans Affairs Cooperative Study Group on Hemodialysis Access Graft Thrombosis randomized controlled trial of clopidogrel plus aspirin to prevent hemodialysis access graft thrombosis. J Am Soc Nephrol 2003 14 2313-2321. 

Coleman Cl. Tuttle LA, Teevan C, Baker WL, White CM. Reinhart KM Antiplatelet agents for the prevention of arteriovenous fistula and graft thrombosis a meta analysis. Int) Chn Pract 2010 64 1239 1244. 

The most serious vascular complication is arterial and venous graft thrombosis and can result in intestinal graft necrosis necessitating graft enterectomy. Typically, contrast-enhanced CT displays either an intraluminal filling defect or complete occlusion of the involved artery with non-enhancement of the intestinal wall indicating graft necrosis (Fig. 7.44d). Sometimes an intraluminal membrane can be ob-... 

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