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GPCR G-protein coupled

Figure 1.1 Distribution of marketed drugs by biochemical target class. GPCRs = G-Protein coupled receptors. Figure 1.1 Distribution of marketed drugs by biochemical target class. GPCRs = G-Protein coupled receptors.
ECM extracellular matrix GPCR G-protein-coupled receptor... [Pg.964]

List of Abbreviations GPCRs, G-protein coupled receptors PDB, protein database SCRs, structurally conserved regions SVRs, structurally variable regions... [Pg.294]

Receptors GPCRDB http //www.gpcr. G-protein coupled... [Pg.18]

Fig. 3 A AGS proteins isolated in yeast-based functional screen G-protein signaling modulator (GPSM) as named by the Human Genome Nomenclature Committee. The major sites of action of AGS proteins in the context of the G-protein activation-deactivation cycle are indicated B on the right. (GPR G-protein regulatory, GEF guanine nucleotide exchange factor, GDI guanine nucleotide dissociation inhibitor, GPCR G-protein coupled receptor)... Fig. 3 A AGS proteins isolated in yeast-based functional screen G-protein signaling modulator (GPSM) as named by the Human Genome Nomenclature Committee. The major sites of action of AGS proteins in the context of the G-protein activation-deactivation cycle are indicated B on the right. (GPR G-protein regulatory, GEF guanine nucleotide exchange factor, GDI guanine nucleotide dissociation inhibitor, GPCR G-protein coupled receptor)...
Yabuki, Y., Muramatsu, T., Hirokawa, T., Mukai, H. and Suwa, M. (2005) GRIFFIN a system for predicting GPCR-G-protein coupling selectivity using support vector machines... [Pg.53]

Sreekumar, K. R., Huang, Y., Pausch, M. H. and Gulukota, K. (2004) Predicting GPCR-G-protein coupling using hidden Markov models. Bioinformatics 20, 3490-3499. [Pg.54]

Neuropharmacologic classification of addictive drugs by primary target (see text and Table 32-1). DA, dopamine GABA, 7-aminobutyric acid GHB, 7-hydroxybutyric acid GPCRs, G protein-coupled receptors THC, A9-tetrahydrocannabinol. [Pg.716]

Figure 2 Known second-messenger pathways that modulate capsaicin or VRs. GPCR, G protein-coupled receptors PLA2, phospholipase A2 AC, adenylate cyclase IP3, inositoltriphosphate DAC diacylglycerol LM, lipoxygenase metabolites AA, arachidonic acid ANA, anandamide PG, prostaglandins Gq/11, Gq/j, Gs, trimeric G-proteins (adapted from Premkumar, 2001)... Figure 2 Known second-messenger pathways that modulate capsaicin or VRs. GPCR, G protein-coupled receptors PLA2, phospholipase A2 AC, adenylate cyclase IP3, inositoltriphosphate DAC diacylglycerol LM, lipoxygenase metabolites AA, arachidonic acid ANA, anandamide PG, prostaglandins Gq/11, Gq/j, Gs, trimeric G-proteins (adapted from Premkumar, 2001)...
Abbreviations-. GPCR = G protein coupled receptor RXR = retinoid X receptor RTK = receptor tyrosine kinase RSTK = receptor serine/threonine kinase RACK = receptor for activated protein kinase C MAPK = mitogen-activated protein kinase. [Pg.217]

G-protein-coupled receptor (GPCR) G-protein-coupled receptor is a receptor superfamily. Members of the G-protein-coupled receptor superfamily are characterized by having seven transmembrane a-helices. [Pg.399]

RGS proteins can also modify GPCR-G-protein coupling in an agonist-selective manner. For example, in pancreatic acinar cells, RGS4 inhibits muscarinic signaling... [Pg.214]

TM, seven transmembrane domain DOR, Drosophila odorant receptor EAG, electroantennogram GFP, green fluorescent protein GPCR, G-protein coupled receptor GR, gustatory receptor nsyb, neuronal synaptobrevin OR, odorant receptor OSN, olfactory sensory neuron PCR, polymerase chain reaction PN, projection neuron RT-PCR, reverse transcription-polymerase chain reaction SOG, subesophageal ganglion. [Pg.587]


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