Good Field Practice

Most chemical grouts are used at field concentrations that preclude gelation at all or at effective gel times when groundwater dilution exceeds 100%. Thus, dye concentration should be such that one-to-one dilution renders the dye unidentifiable. This kind of close control cannot be exercised except by careful measurement of dye and water weights or volumes. The practice of dumping a little dye from its container into a drum of water until the color looks right is totally inadequate for good field practice. 

In order to use any of the results obtained by objective methods as the basis for the acceptance or rejection of a product, there must be available reliable information as to the relationship between the values obtained and organoleptic quality in terms of consumer acceptance and utility. Where standards are based upon measurement of such labile constituents as ascorbic acid or sugar, a knowledge of the normal values for good commercial practice is necessary. Such values have not yet been adequately established. This should constitute a useful field for research of inestimable value to the industry. 

Since the U.S. vs. Barr decision in 1993 (relevant to pharmaceuticals and related fields, rules applied by the Federal Food Drug Administration, FDA), outlier tests may no longer be applied to physicochemical tests, under the assumption that such test methods, having been optimized and validated for the particular set of circumstances, rarely produce outliers. These tests may not be applied to CU results at all. Good manufacturing practices mandate that operators work according to pre-set procedures and write down any observed irregularities as they... 

Training course (documented) in Good Laboratory/Field Practices. 

At this stage in planning, the essential study design information listed below should be determined and a written study plan (i.e., protocol) including these key study details prepared. A formal, pre-approved study plan is required for field soil dissipation studies conducted under Good Laboratory Practice (GLP). A written study plan for non-GLP studies is highly recommended since the document serves as valuable guidance for study personnel. 

Plot maintenance B Expertise must be available to maintain the test site and, if cropped, to take care of the crop For bare-soil studies, the soil surface must be carefully prepared prior to test substance application and kept weed-free without disturbing the test areas. If the test is cropped, the crop should be treated according to Good Agricultural Practice. In case of a soil accumulation study, the field may be cultivated and cropped each season for up to 6 years... 

Today, much more than just data are produced electronically. Many documents needed for studies that fall under the Good Laboratory Practice (GLP) standards regulations are being managed electronically. These records include not only data, such as chromatographic data from automated electronic capture systems and raw data collected in electronic field notebooks, but also other documents, such as methods, protocols, reports and standard operating procedures (SOPs). Frequently, these records are generated, distributed, reviewed, and archived electronically. 

Successful applications of the SPMD technology under a wide variety of field conditions have been demonstrated by a number of researchers (see Appendix B or CERC, 2004). The common threads among successful applications of SPMDs are a basic understanding of potential sources of sample contamination and losses, the functional aspects of the SPMD technique, and the adherence to sound sampling approaches and good laboratory practices. 

Traditionally, the education that chemists and chemistry laboratory technicians receive in colleges and universities does not prepare them adequately for some important aspects of the real world of work in their chosen field. Today s industrial laboratory analyst is deeply involved with such job issues as quality control, quality assurance, ISO 9000, standard operating procedures, calibration, standard reference materials, statistical control, control charts, proficiency testing, validation, system suitability, chain of custody, good laboratory practices, protocol, and audits. Yet, most of these terms are foreign to the college graduate and the new employee. 

The logistics of large phase 3a trials are extremely complicated and require considerable manpower in the headquarters and in the field. Full compliance to Good Clinical Practice (GCP) as well as scientific integrity are prerequisites for the acceptability of these trials to the regulatory authorities, and the pivotal trials undergo detailed inspection to safeguard these... 

In the field of analytical chemistry and pharmaceutical formulations there is a growing awareness of quality issues. To mention a few. Good Laboratory Practice (GLP) and Good Manufacturing Practice (GMP) and ISO norms are important topics in both laboratory and industrial environments. Moreover, there is a growing number of regulatory committees concerned with all aspects of quality, both on a national and international level [1-3]. 

Until further information is obtained on the response of citrus trees to differences in the composition of petroleum oil, estimation of the practical value of the differences indicated between the two series of petroleum fractions on the basis of viscosity, in the control of citrus red mite, is limited. However, the conventional spray oils used in southern Califomia for the control of citrus red mite are applied at dosages six to seven times the LDm values indicated in Figiue 4 for oils having a molecular weight of 340 or above. Proper selection of oils with respect to molecular weight might make it possible to achieve good field control of citrus red mite with applications of much smaller amounts of oil. 

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