Goniothalamus

In synthetic applications, Li et al. examined the propargylation-allenylation of carbonyl compounds by using a variety of metals including Sn, Zn, Bi, Cd, and In.203 By using the indium-mediated allenylation reaction, Li and co-workers developed the synthesis of the antiviral, antitumor compound (+)-goniofufurone (Scheme 8.22),204 a key component isolated from the Asian trees of the genus Goniothalamus,205 and other styryl lactone derivatives (Eq. 8.80). 

Fig. 101. Typical flower of Goniothalamus (Goniothalamus scortechinii King). The figure shows the veined petals and sepals.

Qoniothalamus species. Six Goniothalamus species are used in the traditional medicinal Asian system, and most of these have been used in Malaysia in connection with... 

Fig. 103. Goniothalamus tapis. From Flora of Malaya. FRI No 19803. Geographical localization Le Song F.R. Pahang, low undulating seasonal swamp primary forest, alt 100 feet. Det Y. C. Chan. 

Fig. 104. Examples of cytotoxic acetogenins from Goniothalamus species.

National Park of Variant in the central province of Papua New Guinea, and from the Goniothalamus borneensis Mat-Salleh collected in Malaysia (84). 

A critical factor for Goniothalamus use as a medicinal herb is its content of styryl-lactones, which promote apoptosis in mammalian cells. One might set the hypothesis that the abortifacient and/or postnatal and anti-inflammatory traditional uses of Goniothalamus... 

Lu Z, Yan Z, McLaughlin JL. Gigantransenins A, B, and C, novel mono-THF acetogenins bearing trans-double bonds, from Goniothalamus giganteus (Annonaceae). Tetrahedron Lett 1996 37 5449-5452. 

Feras QA, Yan Z, Lingling R, McLaughlin JL. Mono-tetrahydrofuran acetogenins from Goniothalamus giganteus. Phytochemistry 1998 49 761-768. 

Jiang Z, Chen Y, Ruo-Yun CH, De-Quan Y. Mono-tetrahydrofuran ring acetogenins from Goniothalamus donnaiensis. Phytochemistry 1997 46 327-331. 

Ying C, Zhong J, Ruo RC, et al. Two linear acetogenins from Goniothalamus gardneri. Phytochemistry 1998 49 1317-1321. 

Seidel V, Bailleul F, Waterman PG. Goniothalamusin, a linear acetogenin from Goniothalamus gardneri. Phytochemistry 1999 52 1101-1103. 

Almudena B, Amparo BM, Rao SK, Cortes D. Styryl-pyrones from Goniothalamus arvensis. Phytochemistry 1998 47 1375-1380. 

Hisham A, Toubi M, Shuaily W, Ajitha MDB, Fujimoto Y. Cardiobutanolide, a styryl-lactone from Goniothalamus cardiopetalus. Phytochemistry 2003 62 597-600. 

Hisham A, Harassi A, Shuaily W, Shizue E, Fujimoto Y. Cardiopetalolactone a novel styryllactone from Goniothalamus cardiopetalus Tetrahedron 2000 56 9985-9989. 

Steven MC, Laily BD, Abdul L, et al. ( + )Isoaltholactone a furanopyrone isolated from Goniothalamus species. Phytochemistry 1990 29 1701-1704. 

Wang S, Zhang YJ, Chen RY, Yu DQ. Goniolactones A-F, six new styrylpyrone derivatives from the roots of Goniothalamus cheliensis. J Nat Prod 2002 65 835-841. 

Lan YH, Chang FR, Liaw CC, Wu CC, Chiang MY, Wu YC. Digoniodiol, deoxygo-niopypyrone A, and goniofupyrone A three new styryl-lactones from Goniothalamus amuyon. Planta Med 2005 71 153-159. 

Hasan CM, Mia MY, Rashid MA, Connolly JD. 5-Acetoxyisogoniothalamin oxide, an epoxystyryl lactone from Goniothalamus sesquipedalis. Phytochemistry 1994 37 1763-1744. 

Fasihuddin BA, Wan AT, Siraj O, Atan MS. 5-Acetyl goniothalamin, a styryl dihy-dropyrone from Goniothalamus uvaroides. Phytochemistry 1991 30 2430-2431. 

Seidel, V., Bailleul, F., and Waterman, P.G., (Re/)-l(3,2a-di-(2,4-dihydroxy-6-methoxybenzoyl)-3(3,4a-di-(4-methoxyphenyl)-cyclobutane and other flavonoids from the aerial parts of Goniotha-lamus gardneri and Goniothalamus thwaitesii, Phytochemistry, 55, 439, 2000. 

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