Gonadotropin Luteinizing hormone

LHRH is a decapeptide hormone (pGlu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH2) which is synthesized in the hypothalamus and induces the release of gonadotropins, luteinizing hormone (LH) and follicle-stimulating hormone (FSH) into the systemic circulation. LHRH agonists are commonly used to treat prostate cancer, while antagonists of LHRH are useful for many indications in men and women, such as breast and prostate cancer. 

It is well known that the pituitary gonadotropins, luteinizing hormone (LH) and follicle-stimulating hormone (FSH), are indispensable for ovulation. FSH, in particular, is necessary for the stimulation of preovulatory ovarian estrogen production and the initiation of follicle maturation. This chapter will discuss the mechanisms underlying the FSH stimulation of ovarian cell differentiation and maturation. 

Abdallah, M. A., Lei, Z. M., Li, X., Greenwold, N., Nakajima, S. T., Jauniaux, E., and Rao Ch, V. (2004). Human fetal nongonadal tissues contain human chorionic gonadotropin/ luteinizing hormone receptors. J Clin Endocrinol Metah 89, 952-956. 

Continued reproductive potential in aging platyfish as demonstrated by the persistence of gonadotropin, luteinizing hormone-releasing hormone and spermatogenesis, Mech. Ageing Devel., 22 105. 

Chorionic gonadotropin (CG) is produced in the placenta. Together- with the pituitary hormones, luteinizing hormone (LH) and follicle-stimulating hormone (FSH), it constitutes the glycoprotein family of gonadotropins. The actions of CG are mediated by the LH receptor, both belonging to the superfamily of G-protein Coupled Receptors. 

Chorionic gonadotropin. Follicle stimulating hormone Urea, Uric add. Bilirubin, Cortisol, n-Maimitol. n-Glucose, Sodium pyruvate, 4-hydroxy-3-methoxy mandelic add, 4-Nitro-phenol, 17 Amino adds in HQ, Angiotensin-I, Tripahnitin, Bone meal (8 elements), Bone ash (8 elements), lithium carbonate Luteinizing hormone. Thyroid stimulating hormone... 

The gonadotropins, follicle-stimulating hormone and luteinizing hormone, exert their effects on the gonads (ovaries in the female and testes in the male). Taken together, the gonadotropins stimulate the gonads to ... 

Rao, C. and Sanfilippo, J. 1997. New understanding in the biochemistry of implantation - potential direct roles of luteinizing hormone and human chorionic gonadotropin. Endocrinologist 7(2), 107-111. 

Epinephrine and norepinephrine stimulate the hypothalamus to secrete gonadotropin-releasing hormone, which stimulates the anterior pituitary to secrete bursts of gonadotropins, follicle-stimulating hormone (FSH), and luteinizing hormone (LH). 

Indrapichate, K., Meehan, D., Lane, T. A., et al. (1992) Biological actions of monoclonal luteinizing hormone/human chorionic gonadotropin receptor antibodies. Biol. Reprod. 46, 265-278. 

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