Gonad dose

Local dose Whole body and gonad dose ... 

Muller WA. 1967. Radiobiology Gonad dose in male mice after incorporation of strontium-90. Nature 214 931-933. 

Applications Skin surface dose (mSv) Bone marrow dose (mSv) Gonadal dose ... 

Nuclear power plant to critical group (Sweden) X-ray investigation barium meal (intestine) intravenous urography abdomen and lung mean gonadal dose (abdomen), genetically significant dose dental... 

Spironolactone is an antiandrogen which blocks androgen-receptors, alters steroidogenesis by adrenals and gonads and inhibits 5-a reductase. In doses of 100-200 mg daily it reduces sebum production and improves inflammatory acne in women. During treatment, birth control measures are required due to the risk of male fetus feminization. 

Rodgers-Gray, T.P, Jobling, S., and Kelly, C. et al. (2001). Exposure of juvenile roach (Rutilus rutilus) to treated sewage effluent induces dose-dependent and persistent disruption in gonadal duct development. Environmental Science and Technology 35, 462-470. 

The model is designed to calculate americium excretion and time courses for americium levels in the liver, skeleton, and gonads. This output could be used to predict radiation doses to these tissues. 

Decreases in sperm motility and increased acid phosphatase activity were reported to result from oral administration of 0.05 mg/kg lead in drinking water to male rats for 20-30 days in a study from the former U.S.S.R. (Krasovskii et al. 1979). Dystrophic changes of the Leydig cells were reported in gonadal tissues of rats exposed to doses as low as 0.005 mg lead/kg/day. The weaknesses of the study include absence of data on the strain and number of rats used, and the fact that PbB levels were not reported. 

Peak tissue concentrations reached (in pg/kg FW) were 1180 in liver, 880 in fat, 349 in kidney, 248 in lungs, 164 in muscle, 92 in testes, and 68 in brain. Peak concentration in blood of 113 pg/L reached in 8 h 34% of total dose excreted in feces by 12 h after treatment. After 14 days, measurable residues detected in gonad, muscle, fat, and kidney (Ewing et al. 1985)... 

Effective dose equivalent The weighted sum, in sieverts (Sv), of the radiation dose equivalents in the most radiosensitive organs and tissues, including gonads, active bone marrow, bone surface cells, and the lung. 

Issam C, Samir H, Zohra H et al (2009) Toxic responses to deltamethrin low doses on gonads, sex hormones and lipoperoxidation in male rats following subcutaneous treatments. J Toxicol Sci 34 663-670... 

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