Gold standard databases

Availability of Gold Standard Databases for Cardiac Channel SAR 558... 

PSD Gold standard database of three-dimensional macromolecular structures http //www.rcsb.org/pdb/... 

S.5.5.2.3 Historical controls Since many clinical trials are conducted in the same diseases, with the same control treatments there is an obvious desire to make the most use of this potentially valuable information. Can we compare the results of a new treatment in a group of patients with a group of control patients extracted from a historical database For example, suppose we are testing a new treatment for migraine headache and 60% of patients improve in the first 2 h post-treatment, compared to 30% in a group of historical control patients treated who had been treated with the current gold standard. Are we able to conclude that the new treatment is preferable to the gold standard ... 

At the epitope level, the Immune Epitope Database and Analysis Resource (IEDB) is the largest immune epitope database so far (http //www.immuneepitope.org/). IEDB has stored more than 65,000 antibody and T-cell epitopes since the database was established in 2004 (9). These immune epitopes cover various species (e.g., humans, nonhuman primates, and rodents) that have been well studied in the areas of infectious diseases (9). Because all stored epitopes in IEDB are manually curated from experimental studies, the data in IEDB have often been used as the gold standard for evaluating in silico epitope prediction tools (10). 

Pharmaceutical companies, individual regulatory authorities and the WHO have databases which facilitate this overview. The use of a standard coding dictionary of adverse event terms is essential for this sort of analysis, and one, MedDRA (Medical Dictionary for Regulatory Activities) has been accepted as the gold standard to be used. Nevertheless, routine review of individual cases by responsible, experienced reviewers is the most essential factor in identifying new signals and ensuring patient protection. 

In summary, several methods exist to identify SNPs in genomic DNA. Although some of them may be useful to enrich for SNP-containing PCR amplicons before traditional DNA sequencing, the commonly used approach of discovering SNPs from aligned sequence data from different individuals remains the gold standard and the basis of the majority of SNPs publicly available in databases. 

Gold, L.S., C.B. Sawyer, R. Magaw, et al. 1984. A carcinogenic potency database of the standardized results of animal bioassay. Environ. Health Perspect. 58 9-319. 

Gold, L.S., Sawyer C.B., Magaw R., Backman G.M., DeVeciana M., Levinson R., Kim Hooper N., Havender R., Bernstein L., Peto R., Pike M., Ames b., 1984, A Carcinogenesis Potency Database of the Standardized Results of Animal Bioassays. Environmental Health Perspectives, 58, 9-319. 

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