Glycosylation Strategies

A novel latent-active glycosylation strategy was reported. This strategy is based on a rhodium-catalyzed isomerization of substituted allyl glycosides followed by a Lewis acid-mediated glycosylation reaction (Scheme 46).76 77... 

The one-pot sequential glycosylation strategy is applied to the convergent total synthesis of the Fla antigen (Scheme 2.22) [105]. The glycosyl fluoride 68 is first... 

Glycosylation Strategies Using Thioglycosides 4.1.6.1 Chemoselective Glycosylations... 

The two-stage glycosylation method (12 —> 14 —> 6, Scheme 5.15) had been introduced to avoid problems related to the competitive incorporation of the acceptor (R H) and the extruded alcohol (ROH) from 12. In this context, more efficient glycosylation strategies (4—>14—>6, Scheme 5.15), which circumvent the competitive aspect, have been studied [58]. 

Fiirstner A, Jeanjean F, Razon P, Wirtz C, Mynott R (2003) Total Synthesis of Woodrosm I— Part 1 Preparation of the Building Blocks and Evaluation of the Glycosylation Strategy. Chem Eur J9 307... 

Scheme 10. The bidirectional glycosylation strategy A polymer-bound saccharide serves as glycosyl acceptor (45—>47) and after glycosylation as glycosyl donor (47- 49). 

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