Bidirectional glycosylation strategy

Scheme 10. The bidirectional glycosylation strategy A polymer-bound saccharide serves as glycosyl acceptor (45—>47) and after glycosylation as glycosyl donor (47- 49). 

E. Bidirectional Glycosylation Strategy for the Solid Phase Synthesis of Oligosaccharides... 

Sohd-phase strategies for glycan synthesis can be broken down into three types donor bonnd, acceptor bonnd, and bidirectional (Fig. 4). In the donor bonnd mode, an excess acceptor is nsed to drive the reaction to completion (or to maximize yields). As the donor in a typical glycosylation reaction is the reactive intermediate, nnprodnctive side reactions correspond... 

Synthetic strategies differ by binding either the glycosyl donor [105] or the glycosyl acceptor to the solid phase. A bidirectional approach [106], which allows for chain elongation in both directions, has also been reported. 

---