Sequential glycosylation strategies

The one-pot sequential glycosylation strategy is applied to the convergent total synthesis of the Fla antigen (Scheme 2.22) [105]. The glycosyl fluoride 68 is first... 

Codee JDC, Litjens REJN, van den Bos LJ, Overkleeft HS, van der Marel GA. Thioglycosides in sequential glycosylation strategies. Chem. Soc. Rev. 2005 34 769-782. 

Sequential Glycosylation Strategies A Focus on Thioglycosides as Donors and Acceptors... 

Codee JDC, Stubba B, Schiattarella M, Overkleeft HS, van Boeckel CAA, van Boom JH, van der Marel GA (2005) A modular strategy toward the synthesis of heparin-like oligosaccharides using monomeric building blocks in a sequential glycosylation strategy. J Am Chem Soc... 

In the traditional approaches of oligosaccharide synthesis, the product of a glycosylation reaction had to be isolated and it required some chemical transformation(s) to make it suitable for the next glycosylation reaction. In some of the synthetic strategies described in Section 5.4, such as in the sequential glycosylations and in the armed-disarmed glycosylations, the product of one... 

One-pot techniques combining two or more (chemo)selective glycosylation steps have been developed. One-pot strategies offer the shortest pathway to oligosaccharides, as the sequential glycosylation reactions are performed in a single flask (pot) and... 

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