Glycosidase inhibitory flavonoids

Fig. 33 Glycosidase inhibitory flavonoids from Sophora flavescens...

Several types of bioactive compounds have been reported from the genus Broussonetia including glycosidase inhibitory alkaloids and aromatase inhibitory or cytotoxic flavonoids. This chapter reviews the biologically active constituents from the genus Broussonetia reported by the end of 2001. 

The methanol extract of Sophora flavescens showed potent glycosidase inhibitory activity. Active components were identified as well-known flavonoid antioxidants including kurarinol (3), maackian (6), isoxanthohumol (7), kuraridin (8), sophoraflavanone G (10), 2/-methoxykurarinone (23), kushenol A (26), 8-prenylkaempferol (63), and (-)-kurarinone (68). All of the flavonoids were effective inhibitors of a-glucosidase and /(-amylase. Interestingly, la-... 

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