3-Glycosidase

Digestion of lactose is facilitated by the p glycosidase lactase A deficiency of this enzyme makes it difficult to digest lactose and causes abdominal discomfort Lactose intolerance is a genetic trait it is treatable through over the counter formulations of lac tase and by limiting the amount of milk m the diet... 

One of the most important differences between cellulose and starch is that animals can digest starch Because the glycosidic linkages m starch are a an animal s a glycosidase enzymes can catalyze then hydrolysis to glucose When more glucose is... 

Glycosaminoglycans Glycose Glyco Serve Glycosidases Glycoside Glycosides... 

Three classes of oral therapeutic agent are available for treating patients with diabetes mellitiis (NIDDM) the arylsulfonylureas (known simply as sulfonylureas), biguanides, and a-glycosidase inhibitors. Since 1977, only the sulfonylureas have been approved for use in the United States, although the other classes are used elsewhere. 

Inhibition of configuration-retaining glycosidases by lactones, piperidines, and tetrazoles 99AG(E)750. 

Sinnlarly, f-i- -casuralme, a pentahydroxy pyrrolizidine alkaloid, is prepared by a tandem [4-i-3 /[3-i-3 cycloadchdon involving nitroalkene, chiral vinyl ether, and vinyl silane This process creates five of the six stereocenters present in this potent glycosidase inhibitor fScheme 8 35 ... 

Shiga toxins and related toxins from E. coli No proteins ( ) 28S rRNA A/-glycosidase Cleavage of 28S rRNA Inhibition of protein synthesis... 

Qlo Glycosidase (Glycoside hydrolase) Aminodeoxyglycosidase [Glycosaminidase] Glycosiduronase [Glycuronidase] Glyculosidonase [Neuraminidase] [Sialidase]... 

Figure 10.31 Synthetic route to oxygenated pyrrolizidine alkaloids, and an aza-C-disaccharide as glycosidase inhibitors.

Rye CS, Withers SG (2000) Glycosidase mechanisms, CurrOpin Chem Biol 4 573-580 Saito M, Yu RK (1995) Biochemistry and function of sialidases. In Rosenberg A (ed) Biology of the sialic acids. Plenum, NY, pp 261-313... 

Zechel DL, Withers SG (2001) Dissection of nucleophilic and acid-base catalysis in glycosidases. Curr Opin Chem Biol 5 643-649... 

Triazoline imino sugar derivatives 297 that are prospective glycosidase inhibitors have been prepared as single diastereomers in high yield via an lAOC reaction of in situ generated azido alkene 296 (Eq. 32) [78]. m-CPBA oxidation of the dithioacetal groups in the 0-acetylated 5-azido-5-deoxydibenzyl dithio-acetal of o-xylose or D-ribose 294 to the bis-sulfone 295, followed by loss of HOAc between C-1 and C-2 provided the lAOC precursor 296. 

Fig. 2.—Possible Formation of an Enzyme-linked Acylal (—X = Carboxylate) from an Aldono-1,5-lactone at the Active Site of a / -Glycosidase (after Sinnot and Souchard ).

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