Glycopolymers carbohydrates

Figure 13.4 A schematic showing some of the frameworks that have been reported for the study of protein-carbohydrate interactions. Carbohydrates are represented as cyclohexane. (Top) Glycodendrimer, carbohydrate-functionalized nanoparticle, and star polymer. (Bottom) Linear glycopolymer, carbohydrate-functionalized protein, and carbohydrate-functionalized surface.

Some reviews have been published on the synthetic carbohydrate-based polymers and glycopolymers [11-15]. However, they refer mainly to poly(vinylsaccharide)s and other conventional functionalized polymers having sugars as groups pendant from the main chain of the polymer. In this chapter we shall describe those sugar-based monomers which lead to polymers having the sugar units incorporated into... 

Other glycopolymers carrying a sialyl Lewisx mimic were obtained by copolymerization of functionalized carbohydrate monomers with acrylamide for... 

The main approaches used for identification of natural isomers of 5,7-diamino-3,5,7,9-tetradeoxynon-2-ulosonic acids and determination of structures of bacterial poly- and oligosaccharides-containing derivatives of these sugars were H and 13C NMR spectroscopy. This could be applied to both intact natural glycopolymers and carbohydrate portions obtained after delipidation of LPS as well as to oligosaccharide fragments and... 

Brandenburg, K., Andra, J., Muller, M., Koch, M.H.J., Garidel, P. Physicochemical properties of bacterial glycopolymers in relation to bioactivity. Carbohydr Res 338 (2003) 2477-2489. 

Polymer adsorption has also been adapted to QCM sensing whereby biofunctional thin films are adsorbed on the crystal surface with non-specific binding controlled by tuning of polymer composition. This approach proved successful as applied to carbohydrate-protein interaction by Matsuura et al. through adsorption of lactose bearing amphiphilic polymers on hydrophobic surfaces which then showed RCA12o and peanut lectin (PNA) affinity [33]. Carbohydrate surfaces prepared by photo insertion into an adsorbed polymer were tested by QCM and showed the predicted affinities [34] while in another example a covalently bound glycopolymer demonstrated Concanavalin A detection ability [35]. 

Keywords Carbohydrate sugar glyco polysiloxane glycopolysiloxane hydrosilylation polymer glycopolymer... 

In a subsequent investigation by the author [ 1 ] multivalent glycopolymers with chain-terminating binding groups, (I), were prepared and used in carbohydrate-mediated biomolecular recognition processes. 

This chapter will give you an overview of recent approaches for drug development, focusing on the function and roles of carbohydrates. O Section 2 will outline the biochemical functions of polysaccharide (neutral polysaccharide, chitin and chitosan, glycosaminoglycan, and synthetic polysaccharides) and glycopolymers and the perspectives of their medicinal/medical use. O Section 3 will outline recent biopharmaceutical research and development, utilizing... 

Neoglycoproteins, liposomes, and glycopolymers have been successfully used to demonstrate that multivalency does indeed amplify carbohydrate-protein binding interactions by factors as high as thousands. However, by their very nature, these neoglycoconjugates have ill-defined chemical structures. They are heterogeneous in size and carbohydrate contents. Additionally, neoglycoproteins have been shown to... 

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