Bacterial glycopolymers

DIAMINO-3,5,7,9-TETRADEOXYNON-2-ULOSONIC ACIDS IN BACTERIAL GLYCOPOLYMERS CHEMISTRY AND BIOCHEMISTRY... 

The present article focuses on the occurrence and characterization of derivatives of 5,7-diamino-3,5,7,9-tetradeoxynon-2-ulosonic acids and presents experimental approaches used to identify them and to elucidate the structures of the bacterial polysaccharides that contain the nonulosonic acids. Recent data on the biosynthesis of these sugars and their role in immune recognition and epitope specificity of bacterial glycopolymers are discussed. 

Brandenburg, K., Andra, J., Muller, M., Koch, M.H.J., Garidel, P. Physicochemical properties of bacterial glycopolymers in relation to bioactivity. Carbohydr Res 338 (2003) 2477-2489. 

The main approaches used for identification of natural isomers of 5,7-diamino-3,5,7,9-tetradeoxynon-2-ulosonic acids and determination of structures of bacterial poly- and oligosaccharides-containing derivatives of these sugars were H and 13C NMR spectroscopy. This could be applied to both intact natural glycopolymers and carbohydrate portions obtained after delipidation of LPS as well as to oligosaccharide fragments and... 

The novel sugars appear to be constituents of important bacterial cell-surface glycopolymers that contribute to pathogenesis. They are structurally related to sialic acids, which are essential components of animal... 

Glycodendrimers are mainly considered in various biomedical fields [39b] because of their high biocompatibility in combination with multivalency and specific interactions that are important, for example, for protein and cell membrane binding and recognition processes. The use of glycopolymers as viral and bacterial antiadhesion drugs and for inhibition of infections is very prominent (see also Sections 6.2 and 6.3). 

Pasparakis, G. Cockayne, A. Alexander, C. Control of bacterial aggregation by ther-moresponsive glycopolymers. J. Am. Chem. Soc. 2007,129, 11014—11015. 

Pasparalds G, Cockayne A, Alexander C (2007) Control of bacterial aggregation by thomoresponsive glycopolymers. J Am Chem Soc 129(36) 1014... 

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