Glycolipids pentasaccharide

For this purpose, Ag zeolite and Ag, developed by Garegg25 and Paulsen,26 respectively, have been widely employed (Scheme 7.6). Reactions using these activators have found practical use in synthetic studies on glycoprotein glycans and glycolipids. For instance, Paulsen reported the chemical synthesis of the core pentasaccharide structure 6 common to all types of Asn-linked glycans, using the Ag... 

The synthetic pentasaccharide showed similar antigenic specificity to the Forssman glycolipid but because of the absence of the lipid portion did not form a stable complex with the Forssman antibody [187],... 

Woodrosin I (65) is an ether-insoluble glycolipid isolated from the stems of Ipomoea tuberosa L. (Merremia tuberosa (L.) Rendle) commonly called woodrose after the shape of its dried calyx (28). Its lactone moiety spans four glucose units to form a 27-membered macrocycle. Further challenges arise from the additional acylation pattern at the periphery of the branched and hence highly hindered pentasaccharide perimeter of this glycoconjugate. 

T. Ziegler, E. Eckhardt, and V. Birault, Synthetic studies toward pyruvate acetal containing saccharides. Synthesis of the carbohydrate part of the Mycobacterium smegmatis pentasaccharide glycolipid and fragments thereof for the preparation of neoantigens,./. Org. Chem., 58 (1993) 1090-1099. 

Thus, the role of sialic acid in JC virus infection has been firmly established. Correspondingly, a linear sialylated pentasaccharide with the sequence NeuAc-a2,6-Gal-pl,4-GlcNAc-(31,3-Gal-(31,4-Glc present on host glycoproteins and glycolipids has been characterized as a specific JC virus recognition motif The crystal structure of the major JC virus capsid protein... 

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