Biodegradable copolymers of DL-lactide and

In the 1990s, Schakenraad, Robinson, and colleagues performed systematic research on nerve regeneration using scaffolds based on biodegradable copolymers of DL-lactide and s-caprolactone [10,11]. Based on this work, the first and only commercialized artificial nerve repair scaffold was prepared from the biodegradable copolymers of DL-lactide and s-caprolactone [P(DLLA-s-CL)] and is now used clinically under the trade name Neurolac [12],... 

Zhu, K.J., Xiangzhou, L., Sbilin, Y. (1986) Preparation and properties of DL-lactide and ethylene oxide copolymers a modifying biodegradable material./owmal of Polymer Science Part C Polymer Letters, 24, 331-337. 

Feng, X.D., Voong, S.T., Song, C.X., Chen, W.Y. (1983). Synthesis and evaluation of biodegradable block copolymers of e-caprolactone and DL-lactide. Journal of Polymer Science Polymer Letters Edition, 21, 59,3-600. 

Experiments in rats (38) have shown that y irradiation decreases the inherent viscosity of lactide/glycolide copolymers and increases the biodegradation rate. The in vivo lifetime of a 92 8 DL-lactide/ glycolide copolymer was decreased from about 40 weeks to about 30 weeks after treatment with 2 Mrad of y irradiation. 

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