Glycoconjugates chemistries

A. Dondoni and A. Marra, Addressing the scope of the azide-nitrile cycloaddition in glycoconjugate chemistry. The assembly of C-glycoclusters on a calix[4] arene scaffold through tetrazole spacers, Tetrahedron, 63 (2007) 6339-6345. 

Doores KJ, Gamblin DP, Davis BG. Exploring and exploiting the therapeutic potential of glycoconjugates. Chemistry 2006 12 656-665. 

However, it is evident that advances in immune system knowledge must be flanked by sound synthetic carbohydrate and glycoconjugate chemistry, which is still a challenging and hard task, even if the synthesis can now rely on efficient methods. It s not unreasonable to believe that, while carbohydrates themselves may not be particularly immunogenic, their conjugation to an appropriate multivalenced structure may work well. 

N.D. Zelinsky Institute of Organic Chemistry Russian Academy of Sciences Laboratory of Glycoconjugate Chemistry Leninsky prospect 47 Moscow 119991 Russia... 

Click chemistry has been particularly active in various fields this year. For example, ample applications of click chemistry have been seen in carbohydrate chemistry. Various /weiido-oligosacchardies and amino acid glycoconjugates were synthesized via an intermolecular 1,3-dipolar cycloaddition reaction using easily accessible carbohydrate and amino acid derived azides and alkynes as building blocks <06JOC364>. The iterative copper(I)-catalyzed... 

A. Alix, S. Chassaing, P. Pale, and J. Sommer, Click chemistry in Cu -zeolites A convenient access to glycoconjugates, Tetrahedron, 64 (2008) 8922-8929. 

This review covers the recent advances in the use of O-glycosyl imidates in oligosaccharide and glycoconjugate synthesis, with emphasis on literature published between 1999 and 2006. However, because of the large volume of work in this area, only the most representative applications will be presented. One can refer to the similar preceding review [381] published in 2000 and another quite comprehensive review [375] on trichloroacetimidate method published in 1994 for earlier application of glycosyl trichloroacetimidates. Trifluoroacetimidate method will be discussed separately in this review in the light of its less popularity in carbohydrate chemistry. 

Roth HD (1992) Structure and Reactivity of Organic Radical Cations. 163 131-245 Rouvray DH (1995) Similarity in Chemistry Past, Present and Future. 173 1-30 Roy R (1997) Recent Developments in the Rational Design of Multivalent Glycoconjugates. 187 241-274... 

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