Click chemistry glycoconjugates

Click chemistry has been particularly active in various fields this year. For example, ample applications of click chemistry have been seen in carbohydrate chemistry. Various /weiido-oligosacchardies and amino acid glycoconjugates were synthesized via an intermolecular 1,3-dipolar cycloaddition reaction using easily accessible carbohydrate and amino acid derived azides and alkynes as building blocks <06JOC364>. The iterative copper(I)-catalyzed... 

A. Alix, S. Chassaing, P. Pale, and J. Sommer, Click chemistry in Cu -zeolites A convenient access to glycoconjugates, Tetrahedron, 64 (2008) 8922-8929. 

Fort and coworkers studied the aggregation and protein binding properties of amphiphilic rod-coil type of glycoconjugates (111 and 112, Fig. 19) synthesized using click chemistry between suitably functionalized precursors [109]. The glycan-functionalized amphiphiles were self-assembled in aqueous medium and their size and morphologies were dictated by the amphiphilic balance (volume fraction of... 

Iglesias-Guerra and coworkers, prepared aziridine galactopyranoside derivatives and studied their anticancer activity. Guo et al. presented efficient one-pot synthesis of tigogenin saponin. Tiwari et al used click chemistry to synthesize triazolyl ethisterone glycoconjugates. D Andrea et al. presented stereoselective synthesis of p-D-GlcNAc-(l 4)-D-Glc disaccharide starting from lactose. Martin and coworkers, presented synthesis of L-sorbose derivatives. Authors made a critical review of the spectral data available in literature. 

Cu-Catalyzed Click Chemistry in the Synthesis of Diverse Glycoconjugates... 

Cul, DIPEA, CH2CI2, rt. 12h Scheme 6.4 Synthesis of ethisterone glycoconjugates via Cu-catalyzed click chemistry. 

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