Metabolism glycoconjugate

Regulation of Glycoconjugate Metabolism in Normal and Transformed Cells... 

Abstract. TPA and RA have significant effects on glycolipid and glycoprotein biosynthetic enzymes in several cultured cell systems. This suggests that these compounds as well as other "tumor promoters" will be useful in further studies on the regulation and control of glycoconjugate metabolism (metabolic perturbants). Butyrate, TPA and RA appear to exert their effects at different points in the cell cycle. These results could mean that tumor promotion, differentiation and virus infection occur at discrete points in the cell cycle. Membrane glycoconjugates may participate in these processes in a dynamic time-dependent way. 

Glycoprotein Galactosyltransferase Assays. In order to further investigate the effects of TPA and RA on glycoconjugate metabolism, UDP-galactose DSG-fetuin galactosyltransferase activity was assayed. Table II shows the results of this study. The effects of TPA and RA on... 

Based on data cited previously it appears that TPA s primary effect is at the cell surface (55, 56). This does not exclude the possibility that TPA is transported and metabolized to an "active" intermediate, which then affects glycosyltransferase activity. However, it is possible (particularly in light of the structural dissimilarity between TPA and RA) that these compounds affect glycoconjugate metabolism in different ways. 

Thus it appears that these drugs act at different points to modify cell cycle behavior. The implications of these results in the regulation of glycoconjugate metabolism and their involvement in tumor promotion remains to be seen. Further studies on changes in glycoconjugate metabolism and cell surface patterns as a function of cell cycle should prove very fruitful. 

J. Baddiley Mechanism and control of the cell wall synthesis in bacteria J. Montreuil Recent data on the structure of the carbohydrate moiety of glycoconjugates. Metabolic and biological implications U. S. Ovodov Structural chemistry of plant glycuronoglycans R Kohn Ion binding on polyuronates—alginate and pectin... 

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