Glycine oxidase

Dopamine mono-oxygenase Coproporphyrin decarboxylase Ethylene receptor Methane oxidase Terminal glycine oxidases CP-x type ATP-ase ATx-1 (Lys 7)... [Pg.338]

Prosthetic groups Flavine Adenine Dinucleotide (FAD) Glycine oxidase, Fumaric hydrogenase, Xanthine oxidase... [Pg.332]

Glycine oxidase converts glycine to glyoxylic acid according to Equation... [Pg.550]

D-Glutamate(D-aspartate) oxidase L-Aspartate oxidase Glycine oxidase... [Pg.1389]

Glycine oxidase (ThiO) catalyzes the oxidation of glycine (1) to the glycine imine 23. The ThiO structure, with A -acetylglycine bound at the active site, has been determined. This structure, as well as the efficient utilization of cyclopropyl glycine as a substrate, supports a hydride transfer mechanism (Figure 7). ... [Pg.551]

Figure 7 (a) Reaction catalyzed by glycine oxidase (ThiO). (b) Active site structure of glycine oxidase showing the Ca hydrogen of A/-acetylglycine positioned for hydride transfer to the flavin cofactor. [Pg.551]

They exist with relatively low activity in peroxisomes in the liver and kidney. The most important D-amino acid oxidase is glycine oxidase, an FAD-containing enzyme that catalyzes the formation of glyoxylate and also acts on D-amino acids to form their corresponding 2-oxoacid. Glyoxylate is further oxidized to COj and formate, HCOO , which is used in one-carbon (Cl) metabolism. [Pg.468]

Glycine is converted to glyoxylic acid by two different pathways oxidation and transamination. Glycine oxidase, an enzyme found in liver and kidney, deami-... [Pg.182]

The enzyme systems to be considered here are those which are relatively specific for a single amino acid and which yield ammonia as a result of the primary oxidation. Only three systems have been investigated sufficiently to warrant inclusion at this time glutamic acid dehydrogenase, glycine oxidase, and D-aspartic acid oxidase. [Pg.14]

A possible pathway of catabolism is through the action of glycine oxidase, which catalyzes the aerobic oxidation only of glycine and sarcosine to yield glyoxylic acid, according to the following equations ... [Pg.53]

Glycine oxidase has been found in the liver or kidney of all animals tested, and is a flavoprotein which can be resolved under acid conditions into a protein and FAD. [Pg.53]

Because of the comparatively large concentration of substrate required for marked activity (Km = 0.04 M), and the narrow alkaline region of pH in which the enzyme is active (pH optimum = 8.3), glycine oxidase is not considered to have any considerable role in the metabolism of glycine. However, the same end result of reaction 1 (Fig. 1) can occur by transamination which has been shown to occur with glycine. The transamination reaction is very much in favor of the formation of glycine and can occur spontaneously with glutamic acid at room temperature. ... [Pg.53]

The L-amino acid oxidases isolated from various animal cells and microorganisms are also flavoproteins, containing FMN, but they likewise are not very specific they act on a number of amino acids, but not on all. Glycine is deaminated neither by D-amino acid oxidases nor by L-amino acid oxidases. Its oxidative deamination is accomplished in the presence of a specific enzyme, glycine-oxidase, in the following manner ... [Pg.210]

Glycine is deaminated to its ketoacid, glyoxylic acid, and ammonium ions by glycine oxidase. [Pg.267]

Adenosine deaminase converts adenosine monophosphate back to inosine monophosphate, liberating ammonia. This sequence of reactions thus provides a pathway for the deamination of a variety of amino acids, linked to transamination, similar to those shown in Figure 9.9 for transamination linked to glutamate dehydrogenase or glycine oxidase. [Pg.273]

Glyoxylate could be formed from glycine mther by the action of glycine oxidase SS) or by transamination SS, 34). Glycine oxidase is a flavoprotein that has been found in liver and kidney. Because of its comparatively high Km value (0.04 M) and its low turnover number it generally is considered not to have any considerable role in the metabolism of gl3rcine. [Pg.85]

En prince A adde hemoique, qui cst un inhibiteur sp ifique de la D-aminoacide-oxydase et de la glycine-oxidase, le tissu bdpatique... [Pg.376]

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