Glutathione-S-transferase gene

Orser CS, J Dutton, C Lange, P Jablonsli, L Xun, M Hargis (1993) Characterization of a Elavobacterium glutathione S-transferase gene involved in reductive dechlorination. J Bacteriol 175 2640-2644. 

Anderer G, Schrappe M, Brechlin AM et al. Polymorphisms within glutathione S-transferase genes and initial response to glucocorticoids in childhood acute lymphoblastic leukaemia. Pharmacogenetics 2000 10 715-726. 

Smith, D. B. and Johnson, K. S. (1988). Single-step purification of polypeptides expressed in Escherichia coli as fusions with glutathione S-transferase. Gene 67, 31 0. 

Orser, C. S., Dutton, J., Lange, C., Jablonski, P., Xun, L. Hargis, M. (1993a). Characterization of a Flavobacterium glutathion S-transferase gene involved in reductive dechlorination. Journal of Bacteriology, 175, 2640—4. 

Determine whether 2,3,7,8-TCDD and oltipraz induce glutathione S-transferase gene expression in S. mansoni... 

Park EY, Cho IJ, Kim SG. Transactivation of the PPAR-responsive enhancer module in chemopreventive glutathione S-transferase gene by the peroxisome proliferator-activated receptor-gamma and retinoid X receptor heterodimer. Cancer Res 2004 64 3701-3713. 

Guy CA, Hoogendoorn B, Smith SK, Coleman S, O Donovan MC, Buckland PR. Promoter polymorphisms in glutathione-S-transferase genes affect transcription. Pharmacogenetics 2004 14 45-51. 

Moffat, G.J., A.W. McLaren, and C.R.Wolff (1994). Involvement of Jun and Fos proteins in regulating transcriptional activation of the human pi class glutathione S-transferase gene in multidrug-resistant MCF7 breast cancer cells. J. Biol. Chem. 269 16397-16402. 

The presence of the combined alleles Ml and Tl, which mark deficiencies in glutathione-.S -transferase genes, increases susceptibility to tacrine hepatotoxicity (5). It would be interesting to use this molecular epidemiological approach to identify the role of combinations of glutathione- -transferase genotypes in other adverse drug reactions. 

CB Pikett, AYH Lu. Glutathione S-transferase gene structure, regulation, and biological function. Annu Rev Biochem 58 743—764, 1989. 

Leaver, M.J., J. Wright and S.G. George. Structure and expression of a cluster of glutathione S-transferase genes from a marine fish, the plaice (Pleuronectes platessa). Biochem. J. 321 405-412, 1997. 

Cloning and analysis of glutathione S-transferase genes of mammals and plants has revealed that there are various gene families however, this analysis has not been accomplished in insects (43)- These enzymes are inducible, but generally not to the degree of the monooxygenases (48.50). 

Glutathione S-transferase gene (CSTP1) Enzyme that activates electrophilic carcinogens Strong immunoreactivity rare in cancer... 

D2. DeJong, J. L., Chang, C. M Whang-Peng, J., Knutsen, T., and Tu, C. P. D., The human liver glutathione S-transferase gene superfamily Expression and chromosome mapping of an Hj, subunit cDNA. Nucleic Acids Res. 16, 8541-8554 (1988). 

K. Nakaichi, K. Imai, S. Hayashi (1993). Polymorphisms of the CYPlAl and Glutathione S-transferase genes associated with susceptibility to lung cancer in relation to cigarette dose in a Japanese population. Cancer Res., 53, 2994-2999. 

Davidson NE, Egner PA, Kensler TW. Transcriptional control of glutathione S-transferase gene expression by the chemoprotective agent 5-(2-pyrazinyl)-4-methyl-i, 2-dithiole-3-thione (oltipraz) in rat liver. Cancer Res 1990 50 2251-2255. 

MCGONIGLE, B., KEELER, S.J., LAU, S.M., KOEPPE, M.K., O KEEFE D.P., A genomics approach to the comprehensive analysis of the glutathione S-transferase gene family in soybean and maize. Plant Physiol., 2000,124, 1105-1120. 

Sharrocks, A. D. (1994). A T7 expression vector for providing N- and C-terminal fusion proteins with glutathione S-transferase. Gene 138,105-108. 

Sirivarasai J, Wananukul W, Kaojarern S, Chanprasertyothin S, Thongmung N, Ratanachaiwong W, et al. Association between inflammatory marker, environmental lead exposure, and glutathione S-transferase gene. Biomed Res Int 2013 2013 474963. 

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