Glucuronosyltransferase substrate specificity

Senafi SB, Clarke DJ, Burchell B. Investigation of the substrate specificity of a cloned expressed human bilirubin UDP-glucuronosyltransferase UDP-sugar specificity and involvement in steroid and xenobiotic glucuronidation. Biochem J 1994 303(pt l) 233-240. 

Cheng Z, Radominska-Pandya A, Tephly TR. Studies on the substrate specificity of human intestinal UDP-glucuronosyltransferases 1A8 and 1A10 [in process citation]. Drug Metab Dispos 1999 27(10) 1165-1170. 

Comparative Toxicokinetics. Syrian hamsters appear to be relatively resistant to the testicular effects of di- -butyl phthalate compared to the rat. A comparative metabolic study with rats and hamsters indicated some quantitative differences between the two species with respect to the excretion of metabolites in the urine. Additional comparative studies, perhaps with other species, may add to our understanding of the mechanisms of toxicity to the male reproductive organs. Since it is well known that there are a wide variety of esterases with varying affinity for different substrates, further information on the substrate specificities of the esterases in various species, and on the enzymes involved in detoxification of di- -butyl phthalate, especially glucuronosyltransferase, could help to understand the biological mechanisms behind the species differences in response to di- -butyl phthalate. 

Substrate Specificity of a Cloned Expressed Human Bilirubin UDP-Glucuronosyltransferase UDP-Sugar Specificity and Involvement in Steroid and Xenobiotic Glucuronidation. 

Studies on the Substrate Specificity of Human Intestinal UDP-Glucuronosyltransferases 1A8 and lAlO. 

Court MH, Krishnaswamy S, Hao Q, Duan SX, Patten CJ, Von Moltke LL, Greenblatt DJ (2003) Evaluation of 3 -azido-3 -deoxythymidine, morphine, and codeine as probe substrates for UDP-glucuronosyltransferase 2B7 (UGT2B7) in human liver microsomes specificity and influence of the UGT2B7 2 polymorphism. Drug Metab Dispos 31 1125-1133... 

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