Glucose, reduction

Burger, H. J., Maas, J., Hammerl, R., Schmidt, D., Strohschein, S., Hemmerle, H., Schubert, G., Petry, S., Kramer, W., Prolonged blood glucose reduction in mrp-2 deficient rats (GY/TR(—)) by the glucose-6-phosphate translocase inhibitor S 3025, Biochim. Biophys. Acta 2002,... 

Besides the methylation step, the following reactions are necessary for the synthesis of dTDP-L-mycarose from dTDP-D-glucose reduction at C-2, inversion of configuration at C-5, and (possibly as the last... 

Systems producing fine-particle insulin aerosols have been tested extensively in humans [156], A clear dose response of glucose reduction and reproducibilities comparable to subcutaneous injections were obtained with an inhaler that combines almost monodisperse insulin particles (MM AD 2-3 pm)... 

The intestinal absorption of caproyl-deri-vatives of insulin was evaluated by measuring plasma glucose reduction after admin-... 

Several alternative methods have been developed to retard this browning reaction. The most prevalent method is to reduce free glucose by a controlled bacteria or yeast fermentation to gluconic acid. The fermentation takes anywhere from 2 to 72 hours and adds considerable expense. With UF, protein concentration and glucose reduction can be accomplished simultaneously. 

Reduction of a furanose ditosylate. Joullid et al. have reported a facile synthesis of a muscarine derivative (4) from the furanose 1, obtainable from D-glucose. Reduction of 1 with lithium aluminum hydride gives a mixture of 2 and 3, considered to be formed via an epoxide (a). Indeed reduction of a, prepared by a standard method, gives the same mixture of 2 and 3. The former product was converted into D-epiallomuscarine (4). 

Compound Dose (mg/kg) Glucose Reduction (%) Triglyceride Reduction (%) ... 

Eudragit SlOO microspheres were prepared using water-in-oil-in-water emulsion solvent-evaporation technique, and their application toward oral insulin delivery was evaluated. Oral administration of PVA-stabilized microspheres in normal albino rabbits (equivalent to 6.6 lU insulin/kg of animal weight) demonstrated a 24% reduction in blood glucose level, with maximum plasma glucose reduction of 76% 3.0% in 2 h, and the effect continued up to 6 h. 

Figure 4.1 (a) Schematic illustration of preparation of GNS/PANI composite (1) synthesis of GNS by glucose reduction of GO, (2) deposition of GNS on stainless steel substrate, and (3) electrodeposition preparation of PANI nanofibers on GNS nanosheets, (b) The molecular structure of PANI (reprinted from [100] with permission from Elsevier). 

Sorbitol Glucose, Reduction of functional group at Pb cathode in aqueous buffer... 

The pharmacokinetics and the pharmacodynamics of these co-crystals were evaluated in vivo with 2 nmol kg doses in somatostatin-treated beagle dogs, an animal model used for acute insulin deficiency. As a control, the time-action profile for the C8-HI molecule was compared to that of insulin. However, the former failed to demonstrate the protracted time action exhibited by the co-crystals, although their biopotencies in glucose reduction were similar. This underlines the necessity of the C8-HI, as part of the co-crystal lattice, for its controlled release action. 

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