Global transient forebrain ischemia

Clemens, J.A., Flo, P.P.K. and Panetta, J.A. (1991). LY178002 reduces rat brain damage after transient global forebrain ischemia. Stroke 22, 1048-1052. 

An early in vivo study in the model of global forebrain ischemia in the gerbil showed that a selective agonist of A3AR, IB-MECA, acutely administered 15 min prior to ischemia, impaired post-ischemic blood flow, increased mortality and exacerbated the loss of hippocampal neurons (von Lubitz et al. 1994). IB-MECA administration 20 min prior to transient middle cerebral ischemia also resulted in a significant increase in infarct size(von Lubitz et al. 2001). 

JA Clemens, DT Stephenson, EB Smalstig, EF Roberts, EM Johnstone, JD Sharp, SP Little, RM Kramer. Reactive glia express cytosolic phospholipase A2 after transient global forebrain ischemia in the rat. Stroke 27 527-535, 1996. 

Ni, B., Wu, X., Su, Y., Stephenson, D., Smalstig, E. B., and Clemens, J. (1998). Transient global forebrain ischemia induces a prolong expression of the caspase-3 mRNA in rat hippocampal pyramidal neurons.. Cereb. Blood Flow Metab. 18, 248—256. 

IL-1 exists in two separate forms (a and P), which have only one-third sequence homology [7]. IL-1 is overexpressed during brain ischemia, as documented by the induction of IL-1 P mRNA synthesis in rats with permanent MCA occlusion, transient global forebrain ischemia, or a ligated carotid artery associated with hypoxia [7,51-57]. The complex functions of IL-1 are mediated by specific cell-surface receptors and regulated by the IL-1 receptor antagonist [7,58]. Two main receptors for IL-1 have been identified type... 

Distribution and Phenotype of Proliferating Cells in the Forebrain of Adult Macaque Monkeys After Transient Global Cerebral Ischemia... 

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