Glial cell-derived neurotrophic factor GDNF

Glial cell-derived neurotrophic factor (GDNF)... 

Ciliary neurotrophic factor (CNTF) and glial cell line-derived neurotrophic factor (GDNF) represent the most recently discovered members of the neurotrophic factor family. These, however, display no homology to the neurotrophins previously discussed. 

Dozens of neurotrophic factors regulate the survival of neurons in the central and peripheral nervous systems (Table 1—3). A veritable alphabet soup of neurotrophic factors contributes to the brain broth of chemicals that bathe and nourish nerve cells. Some are related to nerve growth factor (NGF), others to glial cell line—derived neurotrophic factor (GDNF) and still others to various other neurotrophic factors (Table 1—3). Some neurotrophic factors can trigger neurons to commit cellular suicide by making them fall on their apoptotic swords. The brain seems to choose which nerves live or die partially by whether a neurotrophic factor nourishes them... 

Nutt, J. G. et al. (2003). Randomized, double-blind trial of glial cell line-derived neurotrophic factor (GDNF) in PD. Neurology 60(1), 69-73. 

Ngan, E. S., Shum, C. K., Poon, H. C., Sham, M. H., Garcia-Barcelo, M. M., Lui, V. C., and Tam, P. K. (2008). Prokinetidn-1 (ProK-1) works coordinately with glial cell line-derived neurotrophic factor (GDNF) to mediate proliferation and differentiation of enteric neural crest cell. Biochim. Biophys. Acta. Mol. Cell Res. 1783, 467-478. 

Currendy, there are six members of the neurotrophin family, including nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), glial-cell-line-derived neurotrophic factor, (GDNF), and neurturin , which is structurally related to GDNF," 3 as well as several neurotrophins, NT-3, -4, and -5. 

BDNF was also evaluated in the rat model of PD, and was compared to glial cell line derived neurotrophic factor (GDNF) results of the study showed that GDNF was more effective than BDNF in the model, but that there were no significant benefits from either of these neurotrophic factors (Sun et al., 2005). 

Reilly CE (2001) Glial cell line-derived neurotrophic factor (GDNF) prevents neurodegeneradon in models of Parkinson s disease. J Neurol 248 76-78. 

As a quantitatively measurable specific function of glial cells, the rate of synthesis of three neurotrophic factors (nerve growth factor [NGF] brain-derived neurotrophic factor [BDNF] and glial cell line-derived neurotrophic factor [GDNF]) was measured. In the Ohta et al. (2002) study, the enhancer effect of (-)-BPAP was measured only in the high concentration range. The authors found the amount of NGF, BDNF, and GDNF secreted from astrocytes into the culture medium increased by up to 120,2, and 7 times more, respectively, than those of the control treatment with 0.35 mM (-)-BPAP for 24 h. The (-)-BPAP-... 

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