Glial cell-derived neurotrophic factor

Glial cell-derived neurotrophic factor (GDNF)... 

Eigenbrot, C., Gerber, N., 1997. X-ray structure of glial cell-derived neurotrophic factor at 1.9 A resolution and implications for receptor binding. Nature Struct. Biol. 4, 435-438. 

BDNF, brain derived neurotrophic factor CBF, cerebral blood flow GDNF, glial cell line derived neurotrophic factor NGF, nerve growth factor TfR, transferrin receptor VIP, vasoactive intestinal polypeptide. 

Ciliary neurotrophic factor and glial cell line-derived neurotrophic factor... 

Ciliary neurotrophic factor (CNTF) and glial cell line-derived neurotrophic factor (GDNF) represent the most recently discovered members of the neurotrophic factor family. These, however, display no homology to the neurotrophins previously discussed. 

Many approaches have been taken in therapy of Parkinson disease. As mentioned on p. 1790 enhancing dopamine production by administration of L-dopa or by use of MAO inhibitors is a standard treattment. Experimental gene therapy with a glial cell line derived neurotrophic factor also appears promising.1174 1175... 

Dozens of neurotrophic factors regulate the survival of neurons in the central and peripheral nervous systems (Table 1—3). A veritable alphabet soup of neurotrophic factors contributes to the brain broth of chemicals that bathe and nourish nerve cells. Some are related to nerve growth factor (NGF), others to glial cell line—derived neurotrophic factor (GDNF) and still others to various other neurotrophic factors (Table 1—3). Some neurotrophic factors can trigger neurons to commit cellular suicide by making them fall on their apoptotic swords. The brain seems to choose which nerves live or die partially by whether a neurotrophic factor nourishes them... 

GDNF Glial cell line—derived neurotrophic factors including neurturin, c-REF, and R-alpha... 

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