Ginseng saponins action

Oura, H., S. Hiai, Y. Odaka, and T. Yokozawa Studies on the Biochemical Action of Ginseng Saponin I. Purification from Ginseng Extract of the Active Component Stimulating Serum Protein Biosynthesis. J. Biochemistry (Tokyo) 77, 1057 (1975). 

Ohminami, H., Y. Kimura, H. Okuda, T. Tani, S. Arichi, and T. Hayashi Effects of Ginseng Saponins on the Actions of Adrenalin, ACTH and Insulin on Lipolysis and Lipogenesis in Adipose Tissue. Planta Medica 41, 351 (1981). 

Sung WS, Lee DG (2008) In vitro candidacidal action of Korean red ginseng saponins against Candida albicans. Biol Pharm Bull 31 139-143... 

Kita T, Hata T, Kawashima Y, Kaku T et al. 1981 Pharmacological actions of ginseng saponin in stress mice. J Pharm Dyn 4 381-393... 

Ohminami H, Kimura Y, Okuda H, Tani T et al. 1981 Effects of ginseng saponins on the actions of adrenaline, ACTH and insulin on lipolysis and lipogenesis in adipose tissue. Planta Med 41 351-358... 

Wakabayashi, C., Hasegawa, H., Murata, J., and Saiki, 1. (1997). In vivo antimetastatic action of ginseng protopanaxadiol saponins is based on their intestinal bacterial metabolites after oral administration. Oncol. Res. 9, 411-417. 

The dried roots of Asian ginseng are used for medicinal purposes and its main constituents are triterpene saponins known as ginsenosides or panaxosides. The pharmacologic actions of ginseng include immunomodulatory, anti-inflammatory, antitumor, smooth muscle relaxation, stimulant, and hypoglycemic effects (36). 

This well-known Chinese traditional crude drug which consists of the roots of P. notoginseng cultivated in Yunnan has been used as a tonic and a hemostatic. Recently, it has attracted much attention because of its action in preventing and curing coronary disease. Several Ginseng dammarane saponins, Rb (1.62% yield), Rd (0.32%), Re (0.51%) and Rgi (2.07%) have been isolated from this drug, while the oleanolic acid saponin C-V (= ginsenoside-Ro) could not be detected (85, 88, 89). 

Stimulation of the pituitary-adrenocortical system by the saponins has been recently observed 189, 190) and the effect of the saponins on the action of adrenalin, ACTH and insulin in lipolysis and lipogenesis were investigated 191). Chemopharmacological studies of the hypoglycemic principles in Ginseng have been carried out 192, 193). 

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