Gentamicin Cyclosporine

Avoid concurrent or sequential use of other neurotoxic and/or nephrotoxic drugs with streptomycin sulfate, including neomycin, kanamycin, gentamicin, cephaloridine, paromomycin, viomycin, polymyxin B, colistin, tobramycin, and cyclosporine. 

Cyclosporine A Gentamicin Ifosfamide NSAIDs Streptozocin Mercuric chloride... 

Mentre, F. Mallet, A. Experiences with NPML—appU-cation to dosage individualization of cyclosporine, gentamicin and zidovudine. In The Population Approach Rowland, M., Aarons, L., Eds. Commission of European Communities Luxembourg, 1992 75-90. 

Termeer A, Hoitsma AJ, Koene RA. Severe nephrotoxicity caused by the combined use of gentamicin and cyclosporine in renal allograft recipients. Transplantation 1986 42(2) 220-1. 

Whether these requirements are better met by primary cultures or renal cell lines is still subject of debate and will depend on the type of investigation. Techniques for the isolation and culture of primary cells of the renal tubular epithelium, glomerular mesangial cells, podocytes and endothelial cells have been developed for various species including human. Although cells in primary culture tend to dedifferentiate, the characteristics of those cells are usually closer to the in vivo situation than are animal cell tines, at least for a limited culture period. Primary cultures have been used successfully to study the in vitro effects of numerous nephrotoxins including, cyclosporine A (CsA), gentamicin, mercuric chloride and Ochratoxin A [38-42]. 

Morales JM, Andres A, Prieto C, Diaz Rolon JA, Rodicio JL. Reversible acute renal toxicity by toxic sinergic effect between gentamicin and cyclosporine. Clin Nephrol 1988 29 272. 

Clinically important, potentially hazardous interactions with anticoagulants, ceftobiprole, cyclosporine, demeclocydine, doxycydine, gentamicin, imipenem/cilastatin, methotrexate, minocycline, oxytetracydine, tetracycline... 

Clinically important, potentially hazardous interactions with aminoglycosides, betamethasone, cyclosporine, gentamicin, halothane, inhalational anesthetics, kanamycin, magnesium salts, neomycin, quinidine, streptomycin, succinylcholine, tazobactum, tobramycin... 

Alvesco, Omnaris cyclosporine Forvade, Vistide gentamicin ciprofloxacin Inhibase, Vascace ceftibuten lincomycin lincomycin Pletal ciprofloxacin cimetidine cimetidine... 

F. Mentre and A. Mallet, Experiences with NPML—application to dosage individualisation of cyclosporine, gentamicin and zidovudine, in The Population Approach, M. Rowland and L. Aarons (Eds.). Commission of European Communities, Luxembourg, 1992, pp. 75-90. 

Noninterfering acetaminophen, N-acetylprocainamide, amikacin, amitriptyline, clonazepam, cyclosporine, desipramine, diazepam, digoxin, disopyramide, gentamicin, p-hydrox- q>henobarbital, imipramine, Udocaine, methotrexate, netilmicm, nortriptyline, procainamide, quinidine, salicylic acid, sulfamethoxazole, tobramycin, trimethoprim, valproic add, vancomycin... 

Noninterfering acetaminophen, acyclovir, allopurinol, amoxicillin, amphotericin B, am-picillin, aspirin, azlocillin, bendrofluazide, bumetanide, buprenorphine, carbenidllin, cefazolin, cefotaxime, cefoxitin, ceftazidime, cefuroxime, cephalexin, chlorambucil, chloramphenicol, chlordiazepoxide, chlorpheniramine, chlorpropamide, cyclophosphamide, cyclosporin, C5d arabine, daunorubicin, dextropropoxyphene, dihydrocodeine, domperidone, flucytosine, furosemide, gentamicin, griseofulvin, melphalan, methotrexate, metochlo-pramide, metronidazole, miconazole, nabilone, netilmicin, nicotinamide, nitrazepam, penicillin G, piperacillin, prednisolone, procarbeizine, prochlorperazine, riboflavin, rifampin, sulfamethoxazole, thioguanine, tobramycin, tolbutamide, trimethoprim... 

Noninterfering acetaminophen, N-acetylprocainamide, amikacin, amitriptyline, amlodi-pine, carbamazepine, cefotaxime, ceftazidime, chloramphenicol, ciprofloxacin, cisapride, clindamycin, clonidine, codeine, cyclosporine, digoxin, diphenhydramine, disopyramide, ethosuximide, fluconazole, gentamicin, gentamicin, heparin, labetalol, levothyroxine, li-docaine, lithium, methotrexate, metronidazole, minoxidil, nafcillin, nifedipine, phenobar-bital, phenobarbital, phenytoin, phenytoin, primidone, procainamide, propranolol, quini-dine, ranitidine, salicylic acid, theophylline, tobramycin, tobramycin, valproic acid, warfarin... 

Whiting PH, Simpson JG. The enhancement of cyclosporin A-induced nephrotoxicity by gentamicin. Biochem Pharmacol (1983) 32, 2025-8. 

Decreased magnesium levels, that is, levels of 1.2 mEq/L (0.64 mmol/L) or less, may be noted in patients with conditions that cause excessive urinary loss of magnesium, including poorly controlled diabetes and alcohol abuse, or in patients using drugs such as loop and thiazide diuretics (e.g., Lasix, Bumex, Edecrin, and hydrochlorothiazide), cisplatin (which is used widely to treat cancer), and the antibiotics gentamicin, amphotericin, and cyclosporine. Hypomagnesemia also can... 

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