Genome protein complement

The Proteome is the protein complement expressed by a genome. While the genome is static, the proteome continually changes in response to external and internal events. 

The proteome has been defined as the entire protein complement expressed by a genome. Thus the field of proteomics involves the extensive study of the dynamic protein products of the genome and includes... 

Additionally, the cellular location at which the resultant polypeptide will function often cannot be predicted from RNA detection/sequences nor can detailed information regarding how the polypeptide product s functional activity will be regulated (e.g. via post-translational mechanisms such as phosphorylation, partial proteolysis, etc.). Therefore, protein-based drug leads/targets are often more successfully identified by direct examination of the expressed protein complement of the cell, i.e. its proteome. Like the transcriptome (total cellular RNA content) and in contrast to the genome, the proteome is not static with changes in cellular... 

Abstract Proteomics, the comprehensive analysis of the protein complement of the genome of an organism, is becoming an increasingly important discipline for the identification of disease targets. In addition, the effects of drug treatment and metabolism can now be studied on the protein level in a comprehensive manner. 

The term proteome means the total protein complement of a genome, and pro-teomics means the analysis for proteome. The combination of two-dimensional gel electrophoresis (2-DE) and mass spectrometry (MS) is a proteomic method of high-throughput analysis of protein expression. By using this 2-DE and MS, proteomic studies have identified many proteins that may be involved in the pathogenic mechanism of cancers. These studies analyzed cancer cell lines, as well as cancer tissues or serum from patients. 

Proteomics is concerned with the analysis of the complete protein complements of genomes. Thus proteomics includes not only the identification and quantification of proteins, but also the determination of their localization, modifications, interactions, activities, and functions. This chapter focuses on protein sequences as the sources of biochemical information. Protein sequence databases are surveyed. Similarity search and sequence alignments using the Internet resources are described. 

Proteome refers to protein complement expressed by a genome. Thus proteomics concerns with the analysis of complete complements of proteins. It is the study of proteins that are encoded by the genes of a cell or an organism. Such study includes determination of protein expression, identification and quantification of proteins as well as characterization of protein structures, functions and interactions. The functional classification of proteins in genomes (i.e., proteomes) can be accessed from the Proteome Analysis Database at http //ebi.ac.uk/proteome/ (Apweiler et ah, 2001). 

TransportDB The Institute for Genomic Research Describes the predicted cytoplasmic membrane transport protein complement for organisms whose complete genome sequence is available—includes 288 bacteria (http //www.membranetransport. org/)... 

We define genomics as the study of DNA and the encoding process leading to protein formation. Proteomics is the study of proteins in a cell— identification of the entire protein complement of a cell, tissue, or organisms (the proteome). It includes the study of protein interaction and involves protein sequencing to determine the primary protein structure. 

---