Bacterial genomes

Stuart GW, Berry MW. A comprehensive whole genome bacterial phylogeny using correlated peptide motifs defined in a high dimensional vector space. J Bioinform Comput Biol 2003 l(3) 475-93. 

Key Words Whole-genomemicroarrays comparative genomics bacterial evolution population genetics. 

Koonin, E. V., et al., 1996. Sequencing and analysis of bacterial genomes. Current Biology 6 404-416. 

That bacterial resistance predates the era of clinical use of antibiotics by several hundred millions of years is the recent result of genomic sequence data mining from antibiotic-producing microorganisms. These are supposed to be the inventors of antibiotic resistance genes which they had developed to protect themselves from the lethal action of their own antibiotics [4]. 

Seven subfamilies of eukaryotic Kir channels, each sharing 60% amino acid identity between individual members within each subfamily and 40% identity between subfamilies, are known [1]. In addition, multiple prokaryotic Kir channels (Kirbacl.1-9) are now being identified in bacterial genomes. We will focus on the eukaryotic channels. 

Classical global knockouts may have a developmental or lethal phenotype and thus preclude the analysis of the phenotypic consequences of the lack of a gene in specific tissues in adult animals. With the development of the cre/loxP and flp/FRT systems, it has become possible to excise defined DNA fragments from the genome of specified cells. Cre and Flp are bacterial and yeast recombinases, respectively, which recognize loxP and FRT sequences, respectively. The most common... 

Nitrilases are quite rare in bacterial genomes and less than 20 were reported prior to the application of metagenomics for their detection in environmental DNA [81]. Two studies targeting environmental genomes report the detection of more than 337 novel nitrilases. This has dramatically increased the amount of information about nitrilases, and the newly discovered diversity can be applied for the enantioselective production of hydroxy carboxylic add derivatives [81]. 

Sequences of various bacterial genomes and other information.) Karolinska Institute Nutritional and Metabolic Diseases http // www.mic.ki.se/Diseases/cl8.html (Access to information on many nutritional and metabolic disorders.)... 

Figure 4 Distribution of putative type I BVMO genes among bacterial and fungal genomes (see Table 2).

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