Bacterial genomics

Koonin, E. V., et al., 1996. Sequencing and analysis of bacterial genomes. Current Biology 6 404-416. 

Seven subfamilies of eukaryotic Kir channels, each sharing 60% amino acid identity between individual members within each subfamily and 40% identity between subfamilies, are known [1]. In addition, multiple prokaryotic Kir channels (Kirbacl.1-9) are now being identified in bacterial genomes. We will focus on the eukaryotic channels. 

Nitrilases are quite rare in bacterial genomes and less than 20 were reported prior to the application of metagenomics for their detection in environmental DNA [81]. Two studies targeting environmental genomes report the detection of more than 337 novel nitrilases. This has dramatically increased the amount of information about nitrilases, and the newly discovered diversity can be applied for the enantioselective production of hydroxy carboxylic add derivatives [81]. 

Sequences of various bacterial genomes and other information.) Karolinska Institute Nutritional and Metabolic Diseases http // www.mic.ki.se/Diseases/cl8.html (Access to information on many nutritional and metabolic disorders.)... 

J. Versalovic, T. Koeuth, and J. R, Lupski, Distribution of repetitive DNA sequences in eubacteria and application to fingerprinting of bacterial genomes. Nucleic Acid Re.K. 79 6832 (1991). 

Pseudomonas aeruginosa One of the largest pathogenic bacterial genomes, with an expansion of nutrient transport proteins( 200) and two-component regulatory system proteins( 160) features that likely reflect adaptation to thrive in diverse environments and resist antibiotics... 

Koonin, E. V., Mushegian, A. R., Galperin, M. Y., and Walker, D. R. (1997). Comparison of archaeal and bacterial genomes computer analysis of protein sequences predicts novel functions and suggests a chimeric origin for the archaea. Mol. Microbiol. 25, 619-637. 

In another recent promising development, cyclotides were expressed in E. coli despite the lack of native cystine knot peptides in the bacterial genome. ... 

E. R. M. Tillier, and R. A. CoUins, The contributions of replication orientation, gene direction, and signal sequences to base-composition asymmetries in bacterial genomes. J. Mol. Evol. 50, 249-257 (2000). 

E. P C. Rocha, Is there a role for replication fork asymmetry in the distribution of genes in bacterial genomes. Trends Microbiol. 10, 393-395 (2002). 

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