Genetic profiling

Patient databases with genetic profiles, e.g. for cardiovascular diseases, diabetes, cancer, etc. may play an important role in the future for individual health care, by integrating personal genetic profile into diagnosis, despite obvious ethical problems. The goal is to analyse a patient s individual genetic profile and compare it with a collection of reference profiles and other related information. This may improve individual diagnosis, prophylaxis, and therapy. 

Toxicology ( toxicogenomics), to identify potential human and environmental toxicants, and to find correlations between toxic responses to toxicants and changes in the genetic profiles of the objects exposed to such toxicants... 

Lash LH, Hines RN, Gonzalez FJ, Zacharewski TR, Rothstein MA. Genetics and susceptibility to toxic chemicals do you (or should you) know your genetic profile J Pharmacol Exp Ther 2003 305 403-9. 

Steven Rose Anyone who talks about Jewish genes should bear in mind that the genetic profile of Polish Jews is much more similar to Polish non-Jews than it is to Spanish Jews, for example. There s been some hanky-panky going on here. 

Genetic profiling tools provide additional prognostic information to aid in treatment decisions for subgroups of patients with otherwise favorable prognostic features. 

Aldridge, S., "Customizing Drugs to Individual Genetic Profiles," Genet. Eng. News, 21 (14), 29, 67 (2001). 

Rosenfeld, J.M., Vargas, R., Jr, Xie, W. and Evans, R.M. (2003) Genetic profiling defines the xenobiotic gene network controlled by the nuclear receptor pregnane X receptor. Molecular Endocrinology, 17, 1268-1282. 

IT advances have already had a major beneficial impact on medical product development and registration. Some of the major advances in this area are electronic filing of applications for regulatory approval, RCDC, and clinical trial management software. The application of software to the analysis of the genetic profile of large patient populations is an example of the powerful intersection of pharmacogenomics and IT. 

Lee JS, Thorgeirsson SS (2005). Genetic profiling of human hepatocellular carcinoma. Semin Liver Dis 25 125-132. 

Hence women with BRCAimutations who develop breast or ovarian cancer may not be good candidates for treatment with certain types of chemotherapy agents such as Taxol. Doxorubicin, cisplatin, or other newly discovered agents might be a better choice. In the future, genetic profiling may point the way to optimal treatment of cancer. 

Design of DNA microarrays lead to significant improvement in the field of pharmacogenomics, which deals with the reasons behind individual differences in drug responses, toxicity, and multiple drug resistance and hence, aims to find correlations between therapeutic responses to drugs and the genetic profiles of patients. 

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