Genes apolipoprotein

Baba, Y., Tomisaki, R., Sumita, C., Morimoto, I., Sugita, S., Tsuhako, M., Miki, T., and Ogihara, T., Rapid typing of variable number of tandem repeat locus in the human apolipoprotein B gene for DNA diagnosis of heart disease by polymerase chain reaction and capillary electrophoresis, Electrophoresis, 16, 1437, 1995. 

The genetic basis for the more common late-onset AD appears more complex. Genetic susceptibility is more sporadic and it may be more dependent on environmental factors.9 The apolipoprotein E (apo E) gene on chromosome 19 has been identified as a strong risk factor for late-onset AD. There are three variants of apo E however, carriers of two or more of the apo E4 allele have an earlier onset of AD (approximately 6 years earlier) compared with non-carriers.9 Only 50% of AD patients have the apo E4 allele, thus indicating it is only a susceptibility marker. 

Ni W, Egashira K, Kitamoto S, et al. New anti-monocyte chemoattractant protein-1 gene therapy attenuates atherosclerosis in apolipoprotein E-knockout mice. Circulation 2001 103(16) 2096-2101. 

Li, CM, Clark, ME, Chimento, MF, and Curcio, CA, 2006. Apolipoprotein localization in isolated drusen and retinal apolipoprotein gene expression. Invest Ophthalmol Vis Sci 47, 3119-3128. 

In 1993/1994 a series of publications caused a stir in the AD research community, since for the first time they linked a specific neuropathological process in late-onset AD to a genetic marker. Researchers looking at the composition of plaques found that the protein apolipoprotein E (ApoE) was associated with p-amyloid in the cerebrospinal fluid (CSF) of AD patients (Strittmatter et al., 1993). The gene for ApoE is on the same human chromosome (number 19) which was a risk factor in some AD pedigrees. The gene for ApoE comes in three versions (alleles) Apo s2, Apo s3 and, most importantly, Apo s4 these result in three slightly different variants of the protein. Humans carry two versions of the allele and so can have none, one or two of any of the versions of the Apo... 

Corder EH, Saunders AM, Strittmatter WJ, Schmechel DE, Gaskell PC, Small GW, Roses AD, Haines JL and Pericak-Vance MA (1993). Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer s disease in late onset families. Science, 261, 921-923. 

Aalto-Setala K, Kontula K, Manttari M, Huttunen J, Manninen V, Koski-nen P, et al. DNA polymorphisms of apolipoprotein B and AI/CIII genes and response to gemfibrozil treatment. Clin Pharmacol Ther 1991 50 208-214. 

Apochromatic objectives, 16 471 Apocynaceae, alkaloids in, 2 75 Apodization process, 14 227 apo E gene, and LDL level, 5 136 Apoglucose oxidase (apo-GOD), 14 148 Apolipoprotein B deficiencies, 17 652 Apparel, nylon, 19 766 Apparent bypass... 

E7. Ehrlich, K. C., and Ehrlich, M., Highly repeated sites in the apolipoprotein(a) gene recognized by methylated DNA-binding protein, a sequence specific DNA-binding protein. Mol. Celt. Biol. 10, 4957-4960 (1990). 

Ichinose, A., Multiple members of the plasminogen-apolipoprotein (a) gene family associated with thrombosis. Biochemistry 31, 3113-3118 (1992). 

W7. Wang, X. L., Wilcken, D. E. L., and Dudman, N. P. B., Early expression of the apolipopro-tein(a) gene Relationships between infants and their parents serum apolipoprotein (a) levels. Pediatrics 89, 401-406 (1992). 

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