Gene-technological modifications

The term enzyme engineering [11] (see Fig. 1) describes a range of techniques from deliberate chemical modification to remodeling a wild-type enzyme by gene technology. Subti-ligase , a mutant of subtilisin BNP , was prepared by Jackson et al. [12] by protein design and used in a further total synthesis of RNase... 

Further increasing the enzyme production yield of the fermentation process and by further optimizing the best strains by gene technology Further improving the cleaning efficacy of the enzyme by specific modifications of the protease molecule (e.g., by protein engineering). 

Section IV describes the structures and functions of the nucleotides and nucleic acids, and covers many major topics such as DNA replication and repair, RNA synthesis and modification, and protein synthesis. It also discusses new findings on how genes are regulated and presents the principles of recombinant DNA technology. 

A developing application of DNA technology uses a DNA chip that contains many small segments of bases of known sequence. Such DNA chips are being used to attack cancers. Cancers occur when defective genes cause cells to divide uncontrollably, but usually the process of protein synthesis also is modified. Different types of cancer result in different modifications to protein synthesis, depending on how the DNA... 

The key feature of the PDA technology is that a far wider biological diversity can be screened computationally than it is possible with exclusively experimental methods. The in silico approach provides unique and original gene modifications whilst maintaining the precise control over the extent and nature of protein modifications. The novel sequences... 

---