Carcinogens nickel compounds

Miura T, Patiemo SR, Sakuramoto T. 1989. Morphological and neoplastic transformation of C3H/10tl/2 Cl 8 mouse embryo cells by insoluble carcinogenic nickel compounds. Environ Mol Mutagen 14 65-78. 

Landolph JR, Verma A, Ramnath J, and Clemens F (2002) Molecular biology of deregulated gene expression in transformed C3H/10T1/2 mouse embryo cell lines induced by specific insoluble carcinogenic nickel compounds. Environmental Health Perspectives 110(Suppl. 5) 845-850. 

Judde JG, Breillout E, Clemenceau C, et al. 1987. Inhibition of rat natural killer cell function by carcinogenic nickel compounds Preventive action of manganese. J Natl Cancer Inst 78 1185-1190. 

Known to be human carcinogens (nickel compounds) Reasonably anticipated to be a human carcinogen (metallic nickel)... 

Kasprzak KS, Hernandez L (1989) Enhancement of hydroxylation and deglycosyla-tion of 2 -deoxyguanosine by carcinogenic nickel compounds. Cancer Res 49 5964-5968... 

Miura T, Patiern SR, Sakuramoto T, Landolph JR (1989) Morphological and neoplastic transformation of C3H/IOT1/2CI 8 mouse embryo cells by insoluble carcinogenic nickel compounds. Environ Mol Mutagen 14 65-78 Miyaki M, Murata I, Osabe M, Ono T (1977) Effect of metal cations on misincor-poration by E. coli DNA polymerases. Biochem Biophys Res Commun 77 854-860... 

AH nickel compounds are considered as suspected carcinogens and are Hsted in the EPA and TSCA s toxic substances inventory. LD q (mice iv) for... 

Nickel compounds Hydrogenations (e.g. Raney nickel) Conversion of synthesis gas to methane Reduction of organo nitro compounds to amines Carcinogenic (nickel subsulphide). Skin sensitization... 

Costa, M., Simmons-Hansen, J., Bedrossian, C. W. M., Bonura, J. and Caprioli, R. M. (1981). Phagocytosis, cellular distribution, and carcinogenic activity of particulate nickel compounds in tissue culture, Cancer Res., 41, 2868-2876. 

Carcinogenic compounds, 9 448 aromatic amine, 9 450 in dye production, 9 296 Carcinogenic elements, in ferrites, 11 59 Carcinogenicity. See also Cancer of acetaldehyde, 25 561 classification scheme for, 13 311 of herbicides, 13 311 hydrazine, 13 590-591 methanol, 16 314 of propylene oxide, 20 811 testing, 25 221-223 of 2,4-D, 13 315 Carcinogenic potential, 25 222 Carcinogenic risk, of nickel compounds, 17 120... 

Moreover, the involvement of hydroxyl radicals in the nickel mediated enhancement of lipid peroxidation has been suggested [348], which may have implications in the carcinogenicity of nickel compounds. The enhancement of lipid peroxidation might be the result of depletion in the level of hepatic glutathione peroxidase. 

Animal experiments have shown that nickel compounds may cause tumours, the carcinogenicity being greater the lower the solubility of the compounds in water [459]. 

Nickel dust and powder are flammable. Most nickel compounds, particularly the salts, are toxic. NiSO is a known carcinogen. 

The lARC has determined that there is sufficient evidence for carcinogenicity to humans for nickel and nickel compounds." ... 

Department of Health and Human Services (DHHS) has determined that nickel and certain nickel compounds may reasonably be anticipated to be carcinogens. The International Agency for Research on Cancer (lARC) has determined that some nickel compounds are carcinogenic to humans and that metallic nickel may possibly be carcinogenic to humans. The EPA has determined that nickel refinery dust and nickel subsulfide are human carcinogens. 

In a population of sinter plant workers, the risk of death from cancer of the lung or nose has not been shown to decrease even 30-40 years after the workers left the sinter plant (Muir et al. 1994). Although the workers left the sintering operation, many were still exposed to nickel compounds, in operations that have not been associated with cancer. The investigators note that persisting nickel deposits could act as carcinogenic agents. 

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