Gene expression-based high throughput

Stegmaier K, Ross KN, Colavito SA et al. Gene expression-based high-throughput screening (GE-HTS) and application to leukemia differentiation. Nat Genet 2004 36 257-263. 

Signature Screening in Laboratory Gene Expression-Based, High-Throughput Screening... 

The cDNA technology is essentially an array-based, high-throughput protocol that determines gene expression and copy number survey of very large numbers of tumors. As many as 1,000 cylindrical tissue biopsies from individual tumors can be distributed in a single tissue microarray. Sections of the microarray also provide targets for parallel in situ... 

Nelson, P.T., Baldwin, D.A., Scearce, L.M., Oberholtzer, J.C., Tobias, J.W., and Mourelatos, Z. 2004. Microarray-based, high-throughput gene expression profiling of microRNAs. Nat Methods 1 155-161. 

Recombinant adenoviruses are versatile tools for gene delivery into mammalian tissue-culture cells. Adenoviruses can infect both dividing and nondividing cells, with efficiencies approaching 100%. Here we describe the use of adenoviruses to express reporter proteins in high-throughput cell-based assays. 

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