Gene expression-based high throughput screening

Stegmaier K, Ross KN, Colavito SA et al. Gene expression-based high-throughput screening (GE-HTS) and application to leukemia differentiation. Nat Genet 2004 36 257-263. 

Signature Screening in Laboratory Gene Expression-Based, High-Throughput Screening... 

Recently (2004), Applied Biosystems have introduced microfluidics cards or low-density gene expression arrays. These cards follow the main Taqman principles, but are based on a 384-well plate design. Therefore, multiple samples and genes can be monitored, quantitatively, at the same time. Maley et al. (2004) have also reported the use of a multiplexed Taqman model for high throughput screening applications. 

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