Gelfoam

Geldanamycins Geldanazines Geldanoxazines Geldart group Gel dyeing Gel electrophoresis Gelfoam... 

Uchida H, Ohishi H, Matsuo N (1990) Transcatheter hepatic segmental arterial embolization using Lipiodol mixed with an anticancer drug and Gelfoam particles for hepatocellular carcinoma. Cardiovasc Intervent Radiol 13 140... 

Transarterial embolization (TAE) By occluding the smaller tumour-feeding arteries, it is possible to achieve a hypoxia-induced necrosis of the HCC. This is more successful if the tumour is encapsulated. Such embolization can be carried out using collagen particles, polyvinyl alcohol, gelfoam or galactose spheres. However,... 

Nadkarni SR, Yalkowsky SH. Controlled delivery of pilocarpine 1 in vitro characterization of gelfoam matrices. Pharm Res 1993 10 109-112. 

Medication can be delivered via the eye in the form of eyedrops or in an ocular device. Sodium or zinc insulin was incorporated into a Gelfoam sponge-based device. An in vitro dissolution test indicated that the release of insulin from the device was proportional to the flow rate of the dissolution medium. An in vivo dissolution experiment provided support for the hypothesis that there was a direct relationship between the prolonged pharmacological response to insulin and its release from the device. The ocular device with or without the aid of an enhancer was placed in the eye of rabbits as an ocular insert and produced a uniform blood glucose-lowering effect of 60% over 8h. The blood glucose... 

In the rabbit brain safety study using P(CPP-SA) 50 50 copolymer, even less of an inflammatory reaction was observed, and the polymer was essentially equivalent to Gelfoam [94]. In a similar brain biocompatibility study conducted in monkeys, no abnormalities were noted in the computer tomography scans and magnetic resonance images, nor in the blood chemistry or hematology evaluations [95]. No systemic effects of the implants were observed on histological examinations of any of the tissues tested [96]. No unexpected or untoward reactions to the treatments were observed. 

NT-4/5 has also been shown to be active on motor neurons both during development and in the adult. Developing facial motor neurons can be rescued after axotomy by application of NT-4/5 in a gelfoam next to the proximal nerve stump (Huges et al., 1993 Koliatsos et al., 1994) while, in axo-... 

TAE is achieved by using co-axial micro-catheters in order to be able to achieve selective embolization. Most radiologists will use either coils (permanent) or gelfoam (temporary) to embolize vessels. The... 

Gelfoam Level of occlusion depends on size and preparation (torpedoes, pledgets, slurry, powder)... 

Choice of embolic material/method is paramount and must be based on the target vascular territory and the desired effect. Ability to reach distal vascular beds. For example, emergent non-selective embolization of a large vascular territory is best accomplished with a potentially temporary occlusive agent such as Gelfoam. 

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