Gelatin commercial preparation

Silexan is a commercial preparation containing 80 mg of the essential oil of L. angustifolia in an immediate release soft gelatin capsule. It is authorized in Germany for the treatment of anxiety and accompanying restlessness states. A number of clinical trials have been performed. 

In the preparation of capsules, various colored empty gelatin capsule shells may be used to hold the powdered drug mixture. Many commercial capsules are prepared with capsule bodies of one color and a different colored capsule cap, resulting in a two-colored capsule. This makes certain commercial products even more readily identifiable than solid colored capsules. For powdered drugs, dispensed as such or compressed into tablets, a generally larger proportion of dye is required (about 0.1%) to achieve the desired hue than with liquid preparations. 

When it was desired to prepare propints with higher potential than those with DNT, nitration went even further, such as to prepare a mixture of N content 16.3%, which contd about 64% of TNEtB and was still oily. Even if nitration of commercial EtB went to completion and the resulting product consisted mostly of TNEtB, it was still nearly liquid at RT (mp ca 21.5°) and a good gelatinizer for NC. Its N content was 17.25% vs 18.5% for commercial TNT (Ref 2)... 

The main commercial use for gelatin is in the preparation of food, approximately 70% of all production used for this purpose, with an additional 15% going to the pharmaceutical industry, and 10% used for photographic film. The remaining 5% is used in wine making, printing, abrasive manufacturing, and paper production. 

Foods are supplemented with vitamin A in the form of standardized preparations of synthetic fatty acyl esters, nowadays chiefly retinyl palmitate. The preparations are available commercially as either dilutions in high-quality vegetable oils containing added vitamin E as an antioxidant or as dry, stabilized beadlets in which the vitamin A is dispersed in a solid matrix of gelatin and sucrose or gum acacia and sucrose. The oily preparations are used to supplement fat-based foods such as margarines the dry preparations are used in dried food products such as milk powder, infant formulas, and dietetic foods (24). 

The bioavailability of vitamin E from a self-emulsifying preparation was evaluated in comparison to a commercially available soybean oil solution in soft gelatin capsule. Vitamin E administered as a self-emulsifying preparation had markedly higher plasma levels compared to the oil solution formulation, and the extent of absorption was increased almost threefold. Moreover, variability between subjects was markedly reduced in the case of the self-emulsifying preparations [32],... 

The HSPAN used in this study was a commercial sample prepared from gelatinized starch (SGP 502 S, Henkel Corp.), which we screened to give a fraction that passed 100 mesh but was retained by 200 mesh. The water content was 14.2%, as determined by drying in an Abderhalden drying apparatus for 4 hr under vacuum (1 mm Hg) at 100°C over P2O5. 

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