Gaucher

Gaucher s disease P-Giucosidase Cer-i-Gic Giucosyiceramide Enlarged liver and spleen, erosion of long bones, mental retardation in infants. 

An elevated activity of serum acid 3-glycerophosphatase was not specific for carcinoma, as Marshall and Amdor found it in 8% of patients with uncomplicated prostatic hyperplasia, in some patients with bone fractures, carcinoma involving the liver, and other diseases of bone and liver. This activity has also been reported to be elevated in 3 of 12 patients with Gaucher s disease. 

Netter, P., Steinmetz, J., Gillet, P., Kessler, M., Bardin, T., Fener, P., Burnel, D., Gaucher, A., Pourel, J. and Bann-warth, B. (1991). Amorphous aluminosilicates in synovial fluid in dialysis-associated arthropathy. Lancet 337, 554-555. 

Lysosomotropic after intravenous injection to treat enzyme deficiencies (e.g., adult Gaucher s disease) Enzymes... 

Cerezyme Imiglucerase Genzyme Treatment of Gaucher s disease... 

Peslherbe, Pierre Louis Gaucher-. Daniel David Palmer alchemy in the creation of chiropractic. Chiropractic History 15, no. 2 (Dec 1995) 22-27. 

Human heart mitochondria Ammonium acetate Biphasic QSTAR SONAR (Gaucher et al., 2004)... 

Gaucher, S.P., Taylor, S.W., Fahy, E., Zhang, B., Wamock, D.E., Ghosh, S.S., Gibson, B.W. (2004). Expanded coverage of the human heart mitochondrial proteome using multidimensional liquid chromatography coupled with tandem mass spectrometry. J. Proteome Res. 3, 495-505. 

Hollak, C.E.M., van Weely, S., van Oers, M.H.J. and Aerts, J.M.F.G. (1994) Marked elevation of plasma chitotriosidase activity. A novel hallmark of Gaucher disease. Journal of Clinical Investigation 93, 1288-1292. 

B. Friedman, K. Vaddi, C. Preston, E. Mahon, J. R. Cataldo, and J. M. A. McPherson, Comparison of the pharmacological properties of carbohydrate remodeled recombinant and placental-derived /i-Glucocerebrosidase Implications for clinical efficacy in treatment of Gaucher disease, Blood, 93 (1999) 2807-2816. 

Gaucher G, Dufresne MH, Sant VP et al (2005) Block copolymer micelles preparation, characterization and application in drug delivery. J Control Release 109 169-188... 

Thrombolytic agent Thrombolytic agent Anticoagulant Haemophilia B Anti-cancer agent Cystic fibrosis Gaucher s disease Fabry disease Hyperuricaemia Mucopolysaccharidosis Oxygen toxicity Pompe disease... 

Grabowski, G. 2005. Recent clinical progress in Gaucher disease. Current Opinion in Pediatrics 17(4), 519-524. 

Zhao, H. and Grabowski. G. 2002. Gaucher disease perspectives on a prototype lysosomal disease. Cellular and Molecular Life Sciences 59(4), 694-707. 

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