Gaucher animal model

A series of pharmacokinetic and ADME studies was performed with imi-glucerase in order to assess clearance and targeting of imiglucerase in vivo. Because there was no suitable animal model for Gaucher disease, these studies were performed in normal animals. 

Tybulewicz V. L. J., Tremblay M. L., LaMarcaM. E., et al. (1992) Animal model of Gaucher s disease from targeted disruption of the mouse glucocerebrosidase gene. Nature 357 407. 

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