Gastrointestinal transit effect

JL Madsen. Effects of gender, age, and body mass index on gastrointestinal transit times. Digest Dis Sci 37 1548-1553, 1992. 

JMC Price, SS Davis, IR Wilding. The effect of fibre on gastrointestinal transit times in vegetarians and omnivores. Int J Pharmaceut 76 123-141, 1991. 

Walsh CT, Rvden EB. 1984. The effect of chronic ingestion of lead on gastrointestinal transit in rats. Toxicol Appl Pharmacol 75 485-495. 

Read NW, McFarlane A, Kinsman RI, Bates TE, Blackball NW, Farrar GBJ, Hall JC, Moss G, Morris AP, O Neill B, Welch I, Lee Y, Bloom SR. Effect of infusion of nutrient solutions into the ileum on gastrointestinal transit and plasma levels of neurotensin and enteroglucagon. Gastroenterology 1984 86 274-280. 

Wald A, Thiel DHV, Hoechstetter L, Gavaler JS, Egler KM, Verm R, Scott L, Lester R. Gastrointestinal transit the effect of the menstrual cycle. Gastroenterology 1981 80 1497-1500. 

Chiba, T., Bharucha, A.E., Thomforde, G.M., Kost, L.J., and Phillips, S.F., Model of rapid gastrointestinal transit in dogs effects of muscarinic antagonists and a nitric oxide synthase inhibitor, Neurogastroenterol. Motil., 14, 535, 2002. 

A. Southgate. The effects of two di- SO084 etary fiber supplements on gastrointestinal transit, stool weight and frequency, and bacterial flora, and fecal bile acids in normal subjects. Me- SO085 tabolism 1977 26(2) 117-128. 

Methyinaltrexone is a quaternary derivative of the opioid antagonist, naltrexone. The addition of the methyl group forms a compound with greater polarity and lower lipid solubility, so that it is poorly absorbed, and does not cross the blood-brain barrier. Methyinaltrexone distributes selectively (>200-fold selectivity) to peripheral receptors. In human trials it prevented morphine-induced delay in gastrointestinal transit time, while sparing centrally mediated analgesic effects. 

The effect of food on gastrointestinal transit and drug absorption of a 125... 

THE EFFECT OF FOOD ON GASTROINTESTINAL TRANSIT AND DRUG ABSORPTION... 

Schultze JDR, Waddington WA, Ell PJ, Parsons GE, Coffin ME, Basit AW. Concentration-dependent effects of polyethylene glycol 400 on gastrointestinal transit and drug absorption. Pharm Res 2003 20(12) 1984-1988. 

Davis, S. S., Khosla, R., Wilson, C. G., and Washington, N. Gastrointestinal transit of a controlled release pellet formulation of tiaprofenic acid and the effect of food. Int. J. Pharm. 35 253, 1987. 

Pharmacological studies with selective agonists have shown that opioid control of intestinal electrolyte transport is predominantly mediated by delta opioid receptors [58], while the gastrointestinal propulsion is under the control of mu receptors [59,60]. The antidiarrheal effects of NEP inhibitors, such as acetorphan, the prodrug of thiorphan, have been compared to those of an opiate agonist, loperamide, in a model of castor oil-induced diarrhea in rats. When administered peripherally, they produced a delayed onset of diarrhea with no reduction in the gastrointestinal transit [61,62], as is commonly observed with loperamide [63],... 

Schulte-Frohlinde, E., Schmid, R., Brand, V., and Schusdziarra, V. 1994. Effect of bovine (3-casomorphin-4-amide on gastrointestinal transit and pancreatic endocrine function in man. In (3-Casomorphins and Related Peptides Recent Developments (V. Brand and H. Teschemacher, eds), pp. 155—160. VCH, Weinheim. 

Constipation is commonly encountered with cyclizine, owing to its anticholinergic effect. It is also a problem with the SHTj-receptor antagonists as a result of increased gastrointestinal transit time, although the incidence appears to be greater with ondansetron. Dry mouth is seen with cyclizine, prochlorperazine and promethazine. Metoclopramide has been documented as causing diarrhoea. 

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