Gastrointestinal system antiemetics

DOMPERIDONE, METOCLOPRAMIDE ANTIMUSCARINICS i efficacy of domperidone on gut motility by antimuscarinics Some effects of metodopramide are considered to be due to t release of ACh and t sensitivity of the cholinergic receptors to ACh. Antimuscarinics prevent the effects on muscarinic receptors The gastrointestinal effects of metodopramide will be impaired, while the antiemetic effects may not be. Thus, concurrent use with antimuscarinics is not advised because of effects on the gastrointestinal system... 

Antiemetics and antivertigo drag s are used cautiously in patients with glaucoma or obstructive disease of the gastrointestinal or genitourinary system, those with renal or hepatic dysfunction, and in older men with possible prostatic hypertrophy. Piromethazine is used cautiously in patients with hypertension, sleep apnea, or epilepsy. Trimethobenzamide is used cautiously in children with a viral illness because it may increase the risk of Reye s syndrome... 

There is now substantial evidence for the presence of endocannabinoid and endovanilloid systems in the GI tract. The anti-inflammatory, anticancer, antiulcero-genic and antiemetic responses to CBi receptor activation holds promise for the future management of gastrointestinal diseases. Thus, exploitation of the endocannabinoid system by facilitation at sites of endocannabinoid activity by preventing cellular re-uptake or reducing EC degradation may enhance beneficial endocannabinoid effects without the psychotropic side-effects found with systemic administration of exogenous cannabinoids. Manipulation of the endocannabinoid... 

The antiemetic and antivertigo dru are contraindicated in patients with known hypersensitivity to these dru, diose in a coma, or those with severe central nervous system (CNS) depression. In general, these dni are not recommended during pregnancy, lactation, or for uncomplicated vomiting in young children. Metoclopramide is contraindicated in patients with a seizure disorder, breast cancer, pheochromocytoma, or gastrointestinal obstruction. Prochlorperazine is contraindicated in patients with bone marrow depression, blood dyscrasia, Fbrkinson s... 

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