Gastrointestinal obstruction

Lubiprostone is contraindicated in patients with a history of mechanical gastrointestinal obstruction. Safety has not been established in pregnant women animal studies indicated the potential to cause fetal loss. Women who could become pregnant should have a negative pregnancy test result prior to beginning therapy with lubiprostone. 

Nausea and vomiting may be manifestations of a wide variety of conditions, including adverse effects from medications systemic disorders or infections pregnancy vestibular dysfunction central nervous system infection or increased pressure peritonitis hepatobiliary disorders radiation or chemotherapy and gastrointestinal obstruction, dysmotility, or infections. 

Symptoms, such as vomiting, respiratory problems, hypotonia, and seizures, in young children often are characteristic of various serious infections, including meningitis and sepsis. Although these are usually accompanied by fever, neonates with sepsis may be hypothermic or euthermic (normal temperature). In the absence of seizures, gastrointestinal obstruction and cardiorespiratory problems are in the differential... 

Friebe A, Mergia E, Dangel O, Lange A, Koesling D. Fatal gastrointestinal obstruction and hypertension in mice lacking nitric... 

Watson WA, Cremer KF, Chapman JA. Gastrointestinal obstruction associated with multiple-dose activated charcoal. J Emerg Med 1986 4(5) 401-7. 

Atkinson SW, Young Y, Trotter GA. Treatment with activated charcoal complicated by gastrointestinal obstruction requiring surgery. BMJ 1992 305(6853) 563. 

Charcoal is generally very safe and few adverse effects from the use of single dose activated charcoal have been reported despite its widespread use. There are no reports of gastrointestinal obstruction associated with single dose activated charcoal. The most common complications of charcoal administration include constipation, diarrhea, and vomiting. Pulmonary aspiration of activated charcoal is a dreaded complication that can result in pneumonitis, obstruction of the respiratory tree, and bronchiolitis obliterans. Aspiration of large amounts of charcoal can be fatal. 

Gastrointestinal obstruction Increased intracranial pressure Peritonitis Metastases Brain Meninges Hepatic Uremia... 

The antiemetic and antivertigo dru are contraindicated in patients with known hypersensitivity to these dru, diose in a coma, or those with severe central nervous system (CNS) depression. In general, these dni are not recommended during pregnancy, lactation, or for uncomplicated vomiting in young children. Metoclopramide is contraindicated in patients with a seizure disorder, breast cancer, pheochromocytoma, or gastrointestinal obstruction. Prochlorperazine is contraindicated in patients with bone marrow depression, blood dyscrasia, Fbrkinson s... 

Bezoars and gastrointestinal obstruction Colestyramine [5], sucralfate, modified-release formulations, guar gum, ion exchange resins [6-8] magnesium salts [9] nifedipine [10,11] psyllium [12] Visual inspection chemical analysis... 

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