Drug absorption gastrointestinal

Ho NFH, JY Park, PF Ni, WI Higuchi. (1983). Advancing quantitative and mechanistic approaches in interfacing gastrointestinal drug absorption studies in animals and man. In WG Crouthamel, A Sarapu, eds. Animal Models for Oral Drug Delivery in Man In Situ and In Vivo Approaches. Washington, DC APh/APS, pp 27-106. 

The systemic availability of an inhaled glucocorticoid represents the additive and complex combination of pulmonary and gastrointestinal drug absorption. Absorption is influenced by many factors, including delivery device, the use of a spacer, the particle size of the inhaled drug, and the absorption and metabolism of the swallowed drug (1). 

Welling PG In uence of food and diet on gastrointestinal drug absorption a rd F fcwrmacokinet Biopharpi 1977 5 291-334. 

Basit, A.W., et al. 2004. The use of formulation technology to assess regional gastrointestinal drug absorption in humans. Eur J Pharm Sci 21 179. 

Dokoumetzidis, A. and Macheras, P., A dispersion-convection model for the study of the gastrointestinal drug absorption, AAPS PharmSci, Vol. 5, No. 4, 2003, pp. R6086. 

Macheras, P. and Argyrakis, P., Gastrointestinal drug absorption Is it time to consider heterogeneity as well as homogeneity Pharmaceutical Research, Vol. 14, 1997, pp. 842-847. 

Permeability and solubility/dissolution are two major determinants of gastrointestinal drug absorption. The prediction of solubility of molecules is more difficult than for lipophilicity. Solubility critically depends on the solid-state properties of compounds. The same compound can exist in amorphous or in several crystalline states and this can result in very different solubility of molecules. The prediction of crystalline properties, represented, for example, by the melting point, is one of the most difficult problems of physical chemistry. Like the octanol-water partition coefficient, water solubility critically depends on the pH and ionization state of molecules. 

Hurwitz A. The effects of antacids on gastrointestinal drug absorption. II. Effect of sulfadiazine and quinine. J Pharmacol Exp Ther (1971) 179, 485-9,... 

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