Gastrointestinal absorption, of drugs

LF Prescott. Gastrointestinal absorption of drugs. Med Clin North Am 58 907-916, 1974. 

L. Z. Benet, A. Greither, and W. Meister, Gastrointestinal absorption of drugs in patients with cardiac failure, in The Effect of Disease States on Drug Pharmacokinetics (L. Z. Benet, ed.), Academy of Pharmaceutical Association, Washington, D.C, 1976, pp. 33-50. 

Bates, T.R. and Gibaldi, M. (1970). Gastrointestinal absorption of drugs. In Current Concepts in the Pharmaceutical Sciences Biopharmaceutics (Swarbrick, J., Ed.). Lea Febiger, Philadelphia, pp. 58-99. 

Table 2.1 Factors influencing gastrointestinal absorption of drugs.

Theoretical Models Describing the Gastrointestinal Absorption of Drugs... 

Ho et al. [5] presented a theoretical model for gastrointestinal absorption of drugs (Figure 2.2), which described the biomembrane as a series of lipoidal and aqueous pores in parallel. 

Barthe L, Woodley J, Houin G (1999) Gastrointestinal absorption of drugs Methods and studies. Fundam Clin Pharmacol 13 154-168. 

Mechanisms involved in the passage of drugs across membranes. (Adapted with permission from Smyth DH. Absorption and Distribution of Drugs. Baltimore Williams Wilkins, 1964 and Forth W and Rummel W (eds.). Pharmacology of Intestinal Absorption Gastrointestinal Absorption of Drugs. Vols. 1 and 2. Oxford, UK Pergammon, 1975). 

The gastrointestinal absorption of drugs may be affected by concurrent use of other agents that (1) have a large surface area upon which the drug can be adsorbed, (2) bind or chelate, (3) alter gastric pH, (4) alter gastrointestinal motility, or... 

FIGURE 1.10 The pH-dependent extent of ionization of hypothetic acidic and basic molecules, having theoretical p7Ca values of 3.5, 7.0, and 10.5. (From Kurz, H., in Pharmacology of Intestinal Absorption Gastrointestinal Absorption of Drugs (W. Forth and W. Rummel, Eds.), Pergamon Press, Oxford, 1975, p. 245.)... 

Kurz, H. 1975. Principles of drug absorption. In Pharmacology of intestinal absorption Gastrointestinal absorption of drugs, eds. W. Forth and W. Rummel, 245. Oxford Pergamon Press. 

T. T. Kararli, Gastrointestinal absorption of drugs, Crit. Rev. Ther. Drug Carrier Systems 6 39-86 (1989). 

The CAT model presupposes that dissolution is instantaneous and therefore the kinetics of the permeation step control the gastrointestinal absorption of drug. This is reflected in the previous equation, which indicates that the effective permeability is the sole parameter controlling the intestinal absorption of highly soluble drugs. 

Kakemi, K. Sezaki, H. Konishi, R. Kimura, T. Murakami, M. Effect of bile salts on the gastrointestinal absorption of drugs 1. Chem. Pharm. Bull. 1970,18, 275-280. 

Goldberg, A.H. Gibaldi, M. Kanig, J.L. Increasing dissolution rates and gastrointestinal absorption of drugs via solid solutions and eutectic mixtures. II. Experimental evaluation of a eutectic mixture urea-acetaminophen system. J. Pharm. Sci. 1966, 55, 482-487. 

Barthe, L. Woodley, J. Houin, G. Gastrointestinal absorption of drugs methods and studies. Fundam. Clin. Pharmacol. 1999,13 (2), 154-168. 

Exploration of the linear modeling techniques and their combination with multivariate adaptive regression splines to predict gastrointestinal absorption of drugs... 

Anna-Lena Ungell, PhD, is associate director of DMPK and bioanalytical chemistry at AstraZeneca R D Molndal. She supports preclinical and pharmaceutical projects relating to absorption as well as the gastrointestinal absorption of drugs. Her experience includes absorption models, mechanisms of drug absorption from the intestinal tract, substance evaluation and basic formulation development. Dr. Ungell has four patents and has written numerous research articles and reviews. 

Although the drug in the formulation has received considerable attention, many of the alterations in the formulation may be considered as chemical changes. Most of what has been reported applies primarily to the gastrointestinal absorption of drugs and may be viewed as attempts to ... 

Table 9.1 Lack of correlation between disintegration time and gastrointestinal absorption of drug from tablet formulation...

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