Gastric acid secretion enterogastrone

Experiments performed in the 1920s and already described showed that acid and food, in particular fat, in the duodenum inhibit gastric secretion. Lim and his collaborator Kosaka made an extract of the duodenal mucosa that, upon intravenous injection into a dog, inhibited food-stimulated acid secretion, and they called the active component of their extract enterogastrone. Kosaka and Lim demonstrated that their extract did not stimulate pancreatic or biliary secretion and therefore did not contain secretin or cholecystokinin. In the 1960s, when it was possible to isolate purer and more potent compounds from the duodenal mucosa, R. A, Gregory extended the definition of enterogastrone to include inhibitors released from the intestine by acid and hypertonic solutions as well as by fat. " ... 

Gastric inhibitory peptide, GIF a polypeptide hormone (for structure, see Secretin) purified from crude preparations of Cholecystokinin (see). GIF has potent enterogastrone activity, i.e. it inhibits secretion of acid and pepsin by the stomach, and inhibits gastric motility. It possesses no significant secretin or cholecystokinin activity, [J.C. Brown J.R.Drybuigh Canad. J. Biochem. 49 (1971) 867-872]... 

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