Garrett

Edward R. Garrett and Oscar E. Araujo College of Pharmacy, University of Florida, Gainesville, FL 3260I 

Introduction - The availability of the drug from the dosage form depends on physical chemical factors, chemical interactions and a priori predictions and confirmations of release in biological systems. 

When aqueous diffusional barriers on each side of the lipoidal membrane are included, Pick s law does not fully hold in this case of protonation of weak bases. The transfer of amidopyrine and salicylic acid through an organic liquid obeys the theoretical equation proposed5. The formation of complexes can modify the rate of transfer of drugs through such barriers and demand modification of the diffusional equations . When micron-sized emulsion droplets act as sinks for drug, equations were derived for micellar solubilization to take into account the possible effects of an  

Schwartz, as part of a continuing and detailed series on model catalysts which simulate penicillinase has studied the mechanism of hydrolysis of penicillin catalyzed by catachol and their pH dependencies. The degra- 

The rate-pH profile a Arrhenius parameters have been determined for echothiophate iodide J, The kinetics show a pH independent solvolysis with 

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The detailed mathematical developments are difficult to penetrate, and a simple but useful approach is that outlined by Garrett and Zisman [130]. If gravity is not important, Eq. 11-36 reduces to... 

Truhiar D G, Garrett B C and Kiippenstein S J 1996 Current status of transition-state theory J. Phys. Chem. 100 12 771-800... 

Truhlar D G and Garrett B C 1980 Variational transition-state theory Acc. Chem. Res. 13 440-8... 

Melissas V S, Truhlar D G and Garrett B C 1992 Optimized calculations of reaction paths and reaction-path functions for chemical reactions J. Chem. Phys. 96 5758... 

Pull derivation of this equation was presented by Garrett and Poladian [6], see also [7, 8, 9],... 

Tanford, C., Kirkwood, J. G. Theory of protein titration curves. I. General equations for impenetrable spheres. J. Am. Chem. Soc. 79 (1957) 5333-5339. 6. Garrett, A. J. M., Poladian, L. Refined derivation, exact solutions, and singular limits of the Poisson-Boltzmann equation. Ann. Phys. 188 (1988) 386-435. Sharp, K. A., Honig, B. Electrostatic interactions in macromolecules. Theory and applications. Ann. Rev. Biophys. Chem. 19 (1990) 301-332. 

The transition state theory of Eyring or its extensions due to Truhlar and coworkers (see, for example, D. G. Truhlar and B. C. Garrett, Ann. Rev. Phys. Chem. 

S. C. DeVito, ia S. C. DeVito and R. L. Garrett, eds.. Designing Safer Chemicals Green Chemistry for Pollution Prevention, American Chemical Society Symposium Series 640, American Chemical Society, Washington, D.C., pp. 194—223. 

H. E. Garrett, Suface Active Chemicals, Pergamon Press, London, 1972. 

Occidental Petroleum Coal Conversion Process. Garrett R D Co. (now the Occidental Research Co.) developed the Oxy Coal Conversion process based on mathematical simulation for heating coal particles in the pyrolysis unit. It was estimated that coal particles of 100-mm diameter could be heated throughout their volumes to decomposition temperature (450—540°C) within 0.1 s. A large pilot faciUty was constmcted at LaVeme, California, in 1971. This unit was reported to operate successfully at feed rates up to 136 kg/h (3.2 t/d). 

A. Sass, "The Garrett Research and Development Company Process for the Conversion of Coal iato Liquid Fuels," paper presented at 65th Annual AIChE Meeting New York, Nov. 29, 1972. 

P. R. Garrett, Defoaming Theoy andindustrialApplications, Sufactant Science Series, Vol. 45, Marcel Dekker, Inc., New York, 1993. 

G. M. Hunt and G. A. Garrett, Wood Preservation, McGraw-Hill Book Co., New York, 1953. 

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