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Ganglioside synaptosomal membranes

Bondy SC, McKee M, Davoodbhoy YM. 1990a. Prevention of chemically induced changes in synaptosomal membrane order by ganglioside GMI and alpha-tocopherol. Biochim Biophys Acta... [Pg.239]

Gangliosides. sialidase and sialvltransferase in the membranes surrounding nerve endings ( synaptosomal membranes )... [Pg.326]

An experimental model for the study of ganglioside behavior in synaptosomal membranes... [Pg.334]

Masserini M, Freire E. Kinetics of ganglioside transfer between liposomal and synaptosomal membranes. [Pg.178]

Several studies indicate that the bulk of brain ganglioside glycosyltransferases are associated with the synaptosome-rich fractions (Roseman, 1970 Di Cesare and Dain, 1972) and after hypoosmotic shock of the crude mitochondrial fraction they are found in the subfractions enriched in synaptic plasma membranes (Den et al., 1975 ... [Pg.279]

FIGURE 5.18 Desialylation/sialylation cycle in the presynaptic membrane. Upon release from synaptic vesicles, cationic neurotransmitters (monoamines) would be glued by the negatively charged polysialylated gangliosides of the presynaptic membrane. To avoid this problem, it has been suggested that those gangliosides may be transiently desialylated by neuraminidase (sialidase), and then resialylated by sialytransferase (sialyl-Tf). The concentration of both enzymes in synaptosomes is consistent with such a scenario. [Pg.127]

Ando, S., Tanaka, Y., and Kon, K., 1986, Membrane aging of the brain synaptosomes with special reference to gangliosides, in Gangliosides and Neuroplasticity (G. Tettamanti, R. W. Ledeen, K. Sandhoff, Y. Nagai, and G. Taffano, eds.), Liviana Press, Podova, pp. 105-112. [Pg.296]

The data of Lapetina et aL (1967) on rat brain cortex seen in Table I are rather similar to those of others listed above. In general, the microsomal and especially the mitochondrial fractions can be further fractionated to yield pinched off nerve endings or synaptosomes. These are essentially of plasma membrane origin and are especially rich in gangliosides and bound acetylcholine. Synaptosomes can be ruptured by osmotic shock to release synaptic vesicles that are virtually free of gangliosides. [Pg.109]


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See also in sourсe #XX -- [ Pg.331 ]




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